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Aldol sensor-inspired fluorescent probes for measuring protein citrullination.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-06-22 , DOI: 10.1039/c9ob02737h Huihong Chen 1 , Hailong Zhao , Lingling Xiang , Haiting Wu , Yunshi Liang , Xin-An Huang , Jing Zhang
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-06-22 , DOI: 10.1039/c9ob02737h Huihong Chen 1 , Hailong Zhao , Lingling Xiang , Haiting Wu , Yunshi Liang , Xin-An Huang , Jing Zhang
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Protein citrullination is an important posttranslational modification on an arginine residue. However, high quality fluorescent probes for measuring the citrullination level and capturing citrullinated proteins are quite limited. Inspired by the similarity between acid-promoted citrulline-labeling reaction and aldol reaction, here we present “turn-on” and “turn-off” fluorescent probes for measuring citrulline levels based on the scaffold of aldol sensors. Further application of the modified probe showed great potential to simultaneously monitor and capture citrullinated peptides.
中文翻译：
Aldol传感器启发的荧光探针，用于测量蛋白质瓜氨酸化。
瓜氨酸化蛋白是精氨酸残基上重要的翻译后修饰。然而，用于测量瓜氨酸水平和捕获瓜氨酸化蛋白的高质量荧光探针是非常有限的。受酸促进的瓜氨酸标记反应和醛醇缩合反应之间相似性的启发，在此，我们介绍了基于醛醇缩合传感器支架测量瓜氨酸水平的“开启”和“关闭”荧光探针。修饰探针的进一步应用显示了同时监测和捕获瓜氨酸化肽的巨大潜力。
更新日期：2020-07-15
中文翻译：
Aldol传感器启发的荧光探针，用于测量蛋白质瓜氨酸化。
瓜氨酸化蛋白是精氨酸残基上重要的翻译后修饰。然而，用于测量瓜氨酸水平和捕获瓜氨酸化蛋白的高质量荧光探针是非常有限的。受酸促进的瓜氨酸标记反应和醛醇缩合反应之间相似性的启发，在此，我们介绍了基于醛醇缩合传感器支架测量瓜氨酸水平的“开启”和“关闭”荧光探针。修饰探针的进一步应用显示了同时监测和捕获瓜氨酸化肽的巨大潜力。
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