Artificial joint replacement is an effective surgical method for treating end-stage degenerative joint diseases, but peripheral bacterial infection of prosthesis can compromise the effect of the surgery. Herein, antibacterial effects of titanium dioxide nanotubes (TNTs) coated with polyhexamethylene guanidine (PHMG) were examined via in vitro and in vivo experiments. TNTs with a pore diameter 46.4 ± 5.9 nm and length of 300–500 nm for the slice and 650–800 nm for the rod were fabricated by anodization. Then, 3.46 ± 0.40 mg and 1.27 ± 0.28 mg of PHMG were coated onto the TNT slice and rod, respectively. In vitro studies of the release of PHMG showed that the antibacterial agent was released in two stages: initial burst release and relatively slow release. In vitro and in vivo antibacterial studies showed that the PHMG-loaded TNTs (PHMG-TNTs) had excellent antibacterial abilities to prevent bacterial infections. Clinical pathological analysis of ...

中文翻译：

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聚六亚甲基胍 (PHMG) 负载 TiO2 纳米管抗菌活性的体外和体内评价。

人工关节置换术是治疗终末期退行性关节病的有效手术方法，但假体周围细菌感染会影响手术效果。在此，通过体外和体内实验检查了涂有聚六亚甲基胍 (PHMG) 的二氧化钛纳米管 (TNT) 的抗菌作用。通过阳极氧化制备孔径为 46.4 ± 5.9 nm、切片长度为 300-500 nm、棒长度为 650-800 nm 的 TNT。然后，分别将 3.46 ± 0.40 mg 和 1.27 ± 0.28 mg 的 PHMG 涂覆在 TNT 切片和杆上。PHMG 释放的体外研究表明，抗菌剂的释放分两个阶段：初始突释和相对缓慢释放。体外和体内抗菌研究表明，负载 PHMG 的 TNTs (PHMG-TNTs) 具有出色的抗菌能力，可以防止细菌感染。临床病理分析...