Pubertal growth spurt assessment guides the timing of intervention for correcting the skeletal discrepancies in dentofacial orthopedics. Serum hormones are being studied for the skeletal age assessment to avoid unnecessary radiographic exposure. The present study is to evaluate the relationship of serum hormones dehydroepiandrosterone-sulfate (DHEA-S), insulin-like growth factor (IGF-1), and cervical vertebral stages (CS stages) in the skeletal age assessment of orthodontics patients around the circumpubertal age. A total of ninety subjects with age ranging from 7 to 21 years were selected and divided into two groups based on the sex (45 males, 45 females). They were further distributed in each group based on the six CS stages determined from the lateral cephalogram. Blood samples from each subject were collected to evaluate the serum DHEA-S and IGF-1 levels by using the enzyme-linked immunosorbent assay (ELISA). Collected data were analyzed in SPSS software with a test of normalcy, unpaired t test, and one-way analysis of variance (ANOVA) followed by the least significant difference (LSD) post hoc comparison test and univariate regression analysis. The highest mean serum hormone levels were found in CS 4 in group A (male) and CS 3 in group B (female). ANOVA results showed that there was a significant difference in the serum hormone levels among the different CS stages in both the groups for both the hormones. Statistically, a significant difference was found between each CS stages for both the hormones except in the DHEA-S levels between CS 5 and CS 6. The mean serum DHEA-S levels followed a typical pattern from the CS 1 till CS 6 which was comparable and similar to the mean serum IGF-1 levels in respect to CS stages. Thus, serum DHEA-S levels could be used as a possible diagnostic test for the assessment of the skeletal pubertal growth spurt in dentofacial orthopedics.

中文翻译：

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血清DHEA-S水平可以用作可比的诊断测试，以评估牙颌骨科的青春期生长突增。

青春期生长突增评估可指导纠正牙颌骨科骨骼差异的干预时间。正在研究血清激素以进行骨骼年龄评估，以避免不必要的射线照相暴露。本研究旨在评估环青春期前后正畸患者骨骼年龄评估中血清激素脱氢表雄酮硫酸盐（DHEA-S），胰岛素样生长因子（IGF-1）和颈椎分期（CS分期）的关系。年龄。总共选择了90名年龄在7至21岁之间的受试者，并根据性别将其分为两组（男性45位，女性45位）。根据从头颅侧位图确定的六个CS阶段，将它们进一步分布在每个组中。收集每个受试者的血样，通过酶联免疫吸附测定（ELISA）评估血清DHEA-S和IGF-1的水平。收集的数据在SPSS软件中进行了正态性检验，不成对t检验和方差单向分析（ANOVA），然后是事后比较检验和单变量回归分析。在A组（男性）的CS 4和B组（女性）的CS 3中发现最高的平均血清激素水平。方差分析结果表明，两种激素的两组在不同CS阶段之间的血清激素水平存在显着差异。从统计学上讲，除了CS 5和CS 6之间的DHEA-S水平外，两种激素在每个CS阶段之间都存在显着差异。从CS 1到CS 6，平均血清DHEA-S水平遵循典型模式，与CS阶段的平均血清IGF-1水平相当。因此，血清DHEA-S水平可以用作评估牙颌骨科骨骼青春期生长突增的可能诊断方法。