Amaranth seed oil (ASO) and rapeseed oil (RSO) are functional foods that display antioxidant and hepatoprotective properties. These oils are also known to lower glucose and cholesterol levels. The current study compared the effects exerted by RSO and ASO on weight loss and metabolic parameters during a 3-week body mass reduction program. Eighty-one obese subjects (BMI > 30 kg/m2), aged 25–70 years, were enrolled in a 3-week body mass reduction program based on a calorie-restricted diet and physical activity. Participants were randomly categorized into an AO group (administered 20 mL/d of ASO), a RO group (administered 20 mL/d of RSO), and a C group (control; untreated). Anthropometric and metabolic parameters were measured at baseline and endpoint. Significant decreases in weight, body mass index (BMI), waist circumference (WC), hip circumference (HC), fat mass (FM), lean body mass (LBM), visceral fat mass (VFM), and total body water (TBW%) were observed in all groups (P < 0.05). No significant improvements were observed in the clinical parameters of group C. Fasting insulin (Δ − 5.9, and Δ − 5.7) and homeostatic model assessment of insulin resistance (HOMA-IR) (Δ − 1.1 and Δ − 0.5) were decreased in both RO and AO groups, respectively. Fasting glucose (Δ -8.5; P = 0.034), total cholesterol (Δ -14.6; P = 0.032), non-HDL cholesterol (Δ 15.9; P = 0.010), TG/HDL ratio (Δ -0.6; P = 0.032), LDL cholesterol (Δ -12.3; P = 0.042), and triglycerides (Δ -6.5; P = 0.000) were significantly improved in the AO group, compared to the RO group. The 3-week body mass reduction intervention caused a significant reduction in the weight, BMI, WC, HC, FM, and VFM of all groups. Except for HOMA-IR, there were no statistical differences between the clinical parameters of all groups. However, a trend toward improved insulin levels and HDL% was noticeable in AO and RO. Therapies involving edible oils with high nutritional value, such as RSO and ASO, show potential for improving metabolic measurements during body mass reduction programs. Thus, obese patients undertaking weight reduction programs may benefit from RSO and ASO supplementation. retrospectively registered, DRKS00017708.

中文翻译：

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在3周的减体重计划后，比较菜籽油或a菜籽油补充剂对肥胖患者的体重减轻，身体组成和代谢状况变化的影响：一项随机临床试验。

mar菜籽油（ASO）和菜籽油（RSO）是具有抗氧化和保肝作用的功能性食品。还已知这些油可降低葡萄糖和胆固醇水平。目前的研究比较了RSO和ASO在3周的体重减轻计划中对减肥和代谢参数的影响。25名70至25岁的肥胖受试者（BMI> 30 kg / m2）参加了为期3周的体重减少计划，该计划基于热量限制饮食和体育锻炼。参与者被随机分为AO组（ASO 20毫升/天），RO组（RSO 20毫升/天）和C组（对照组；未治疗）。在基线和终点测量人体和代谢参数。体重，体重指数（BMI），腰围（WC），在所有组中均观察到臀围（HC），脂肪量（FM），瘦体重（LBM），内脏脂肪量（VFM）和总水分（TBW％）（P <0.05）。C组的临床参数未见明显改善。空腹胰岛素（Δ− 5.9和Δ− 5.7）和胰岛素抵抗的稳态模型评估（HOMA-IR）（Δ− 1.1和Δ− 0.5）均降低RO和AO组分别。空腹血糖（Δ-8.5; P = 0.034），总胆固醇（Δ-14.6; P = 0.032），非HDL胆固醇（Δ15.9; P = 0.010），TG / HDL比（Δ-0.6; P = 0.032）与RO组相比，AO组的LDL胆固醇（Δ-12.3; P = 0.042）和甘油三酸酯（Δ-6.5; P = 0.000）显着改善。为期3周的减少体重干预措施使所有组的体重，BMI，WC，HC，FM和VFM显着降低。除HOMA-IR外，所有组的临床参数之间无统计学差异。但是，在AO和RO中，胰岛素水平和HDL％改善的趋势很明显。涉及具有高营养价值的食用油（例如RSO和ASO）的疗法显示出在减少体重计划期间改善代谢测量的潜力。因此，进行减重计划的肥胖患者可从RSO和ASO补充中受益。追溯注册，DRKS00017708。因此，进行减重计划的肥胖患者可从RSO和ASO补充中受益。追溯注册，DRKS00017708。因此，进行减重计划的肥胖患者可从RSO和ASO补充中受益。追溯注册，DRKS00017708。