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Synthesis of fluorescent MOFs: live-cell imaging and sensing of a herbicide
CrystEngComm ( IF 2.6 ) Pub Date : 2020-06-22 , DOI: 10.1039/d0ce00490a Aurobinda Mohanty 1, 2, 3, 4 , Udai P. Singh 1, 2, 3, 4 , R. J. Butcher 1, 5, 6, 7 , Neeladrisingha Das 2, 3, 4, 8 , Partha Roy 2, 3, 4, 8
CrystEngComm ( IF 2.6 ) Pub Date : 2020-06-22 , DOI: 10.1039/d0ce00490a Aurobinda Mohanty 1, 2, 3, 4 , Udai P. Singh 1, 2, 3, 4 , R. J. Butcher 1, 5, 6, 7 , Neeladrisingha Das 2, 3, 4, 8 , Partha Roy 2, 3, 4, 8
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Various zinc and cadmium containing metal–organic frameworks using the semi-rigid 1,1′-(anthracene-9,10-diylbis(methylene))bis(pyridin-1-ium-4-olate) ligand (L = AHP) and various sulfonic acid analogs [1,5-naphthalenedisulfonic acid (1,5-NDS), 3-sulfobenzoic acid (3-SBA), 4-sulfobenzoic acid (4-SBA), 5-sulfosalicylic acid (SSA), 5-sulfoisophthalic acid (SIA) and 2,6-naphthalenedisulfonic acid (2,6-NDS)] have been synthesized by a hydrothermal method. They have been characterized by powder X-ray diffraction thermogravimetric analysis and single crystal X-ray diffraction methods. The X-ray studies showed that MOF2, 4, and 8 have two dimensional architectures whereas 1, 3, 5, 6 and 7 have three-dimensional structures. The topological analysis demonstrated that all the zinc-containing MOFs have a hexagonal (hcb) net topology with the point symbol of the framework being {63} whereas cadmium-containing MOF4 has an sql net topology with the point symbol of the framework being {44·62} and MOF5 has a hcb net topology with the point symbol of the framework being {63}. Since all synthesized MOFs have fluorescence properties, they have been used as imaging agents for MCF7 cells. The cytotoxic experiments show that more than 92% cells survive at the dose 100 μg ml−1. The cell imaging results show that the MOF particles were found in the cytoplasm rather than in the nucleus and these can be used further as a conjugate with any known anti-cancer drugs in cellular distribution. The emission properties of these MOFs have been utilized for the detection of a herbicide (simazine) as well as nitroaromatic compounds. The quenching constant for PA (picric acid) in MOF7 was found to be 5.01 × 104 M−1, which may be due to the interaction of picric acid and co-ligands present in MOF7.
中文翻译：
荧光MOF的合成：活细胞成像和除草剂传感
使用半刚性的1,1'-（蒽-9,10-二基双（亚甲基））双（吡啶-1-鎓-4-油酸酯）配体（L = AHP）和各种含锌和镉的金属-有机骨架各种磺酸类似物[1,5-萘二磺酸（1,5-NDS），3-磺基苯甲酸（3-SBA），4-磺基苯甲酸（4-SBA），5-磺基水杨酸（SSA），5-磺基间苯二甲酸通过水热法合成了丙烯酸（SIA）和2,6-萘二磺酸（2,6-NDS）]。它们通过粉末X射线衍射热重分析和单晶X射线衍射方法来表征。X射线研究表明，MOF2、4和8具有二维结构，而1,3、5、6和7具有三维结构。3 }，而含镉的MOF4具有sql网络拓扑，框架的点符号为{4 4 ·6 2 }，而MOF5具有hcb网络拓扑，框架的点符号为{6 3 }。由于所有合成的MOF均具有荧光特性，因此它们已用作MCF7细胞的显像剂。细胞毒性实验表明，以100μgml -1的剂量存活的细胞超过92％。细胞成像结果表明，MOF颗粒存在于细胞质而不是细胞核中，并且可以进一步与细胞分布中的任何已知抗癌药物结合使用。这些MOF的发射特性已用于检测除草剂（西马津）和硝基芳香族化合物。发现MOF7中PA（苦味酸）的淬灭常数为5.01×10 4 M -1，这可能是由于苦味酸和MOF7中存在的共配体之间的相互作用。
更新日期：2020-07-06
中文翻译：
荧光MOF的合成：活细胞成像和除草剂传感
使用半刚性的1,1'-（蒽-9,10-二基双（亚甲基））双（吡啶-1-鎓-4-油酸酯）配体（L = AHP）和各种含锌和镉的金属-有机骨架各种磺酸类似物[1,5-萘二磺酸（1,5-NDS），3-磺基苯甲酸（3-SBA），4-磺基苯甲酸（4-SBA），5-磺基水杨酸（SSA），5-磺基间苯二甲酸通过水热法合成了丙烯酸（SIA）和2,6-萘二磺酸（2,6-NDS）]。它们通过粉末X射线衍射热重分析和单晶X射线衍射方法来表征。X射线研究表明，MOF2、4和8具有二维结构，而1,3、5、6和7具有三维结构。3 }，而含镉的MOF4具有sql网络拓扑，框架的点符号为{4 4 ·6 2 }，而MOF5具有hcb网络拓扑，框架的点符号为{6 3 }。由于所有合成的MOF均具有荧光特性，因此它们已用作MCF7细胞的显像剂。细胞毒性实验表明，以100μgml -1的剂量存活的细胞超过92％。细胞成像结果表明，MOF颗粒存在于细胞质而不是细胞核中，并且可以进一步与细胞分布中的任何已知抗癌药物结合使用。这些MOF的发射特性已用于检测除草剂（西马津）和硝基芳香族化合物。发现MOF7中PA（苦味酸）的淬灭常数为5.01×10 4 M -1，这可能是由于苦味酸和MOF7中存在的共配体之间的相互作用。
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