BACKGROUND When persons with multiple sclerosis (MS) report memory decline but objective memory performance is normal, there is a bias toward believing objective test results. OBJECTIVE Investigate whether subjective memory decline or objective memory performance is more related to hippocampal and hippocampal subfield volumes in early MS. METHODS Persons with early MS (n = 185; ⩽5.0 years diagnosed) completed a subjective memory questionnaire; an objective memory composite was derived from four memory tests. Total hippocampal and subfield volumes were derived from high-resolution 3.0 T magnetic resonance images (MRIs). Partial correlations assessed links between hippocampal volumes and both subjective and objective memory, controlling for age, sex, mood, and pre-morbid intelligence quotient (IQ). RESULTS Lower total hippocampal and CA1 volumes were related to worse subjective memory but not objective memory (controlling for multiple comparisons). Correlations between subjective memory and both CA1 and subiculum were significantly stronger than were correlations between objective memory and these subfields. Patients in the worst tertile of subjective memory complaints (but not objective memory) had lower hippocampal volumes than 35 demographically similar healthy controls. CONCLUSION Patient-report is inherently a longitudinal assessment of within-person memory change in everyday life, which may be more sensitive to subtle disease-related changes than cross-sectional objective tests. Findings align with the aging literature.

中文翻译：

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在早期多发性硬化症中，海马体积与患者报告的记忆比客观记忆表现更相关

背景 当多发性硬化症 (MS) 患者报告记忆力下降但客观记忆力表现正常时，就会倾向于相信客观的测试结果。目的调查主观记忆衰退或客观记忆表现是否与早期 MS 的海马和海马亚区体积更相关。方法 患有早期 MS 的人（n = 185；诊断为 5.0 岁）完成了主观记忆问卷；客观的记忆组合来自四个记忆测试。海马总体积和亚区体积来自高分辨率 3.0 T 磁共振图像 (MRI)。部分相关评估海马体积与主观和客观记忆之间的联系，控制年龄、性别、情绪和病前智商 (IQ)。结果 较低的海马总体积和 CA1 体积与较差的主观记忆有关，但与客观记忆无关（控制多重比较）。主观记忆与 CA1 和下托之间的相关性明显强于客观记忆与这些子场之间的相关性。主观记忆抱怨最差（但不是客观记忆）的患者海马体积低于 35 名人口统计学相似的健康对照组。结论 患者报告本质上是对日常生活中个人记忆变化的纵向评估，与横断面客观测试相比，它可能对与疾病相关的细微变化更敏感。研究结果与老化的文献一致。主观记忆与 CA1 和下托之间的相关性明显强于客观记忆与这些子场之间的相关性。主观记忆抱怨最差（但不是客观记忆）的患者海马体积低于 35 名人口统计学相似的健康对照组。结论 患者报告本质上是对日常生活中个人记忆变化的纵向评估，与横断面客观测试相比，它可能对与疾病相关的细微变化更敏感。研究结果与老化的文献一致。主观记忆与 CA1 和下托之间的相关性明显强于客观记忆与这些子场之间的相关性。主观记忆抱怨最差（但不是客观记忆）的患者海马体积低于 35 名人口统计学相似的健康对照组。结论 患者报告本质上是对日常生活中个人记忆变化的纵向评估，与横断面客观测试相比，它可能对与疾病相关的细微变化更敏感。研究结果与老化的文献一致。主观记忆抱怨最差（但不是客观记忆）的患者海马体积低于 35 名人口统计学相似的健康对照组。结论 患者报告本质上是对日常生活中个人记忆变化的纵向评估，与横断面客观测试相比，它可能对与疾病相关的细微变化更敏感。研究结果与老化的文献一致。主观记忆抱怨最差（但不是客观记忆）的患者海马体积低于 35 名人口统计学相似的健康对照组。结论 患者报告本质上是对日常生活中个人记忆变化的纵向评估，与横断面客观测试相比，它可能对与疾病相关的细微变化更敏感。研究结果与老化的文献一致。