Herein, a facile intramolecular cyclization of 2-arylamino phenyl ketones is established to supersede the traditional high-temperature, strongly acidic conditions and achieve 9-substituted acridines, by virtue of the combination of 2,2,2-trifluoroethanol and tert-butyl bromide. This protocol can be merged well with the preceding Cu-catalyzed intermolecular Chan–Evans–Lam cross-coupling reactions, therefore enabling pot-economic modular synthesis of 9-substituted acridines from readily available 2-amino phenyl ketones and aryl boronic acids at room temperature.

中文翻译：

---

叔丁基溴化物促进的2-芳基氨基苯基酮的分子内环化及其与Cu催化的CN偶联的结合：室温下Synthesis啶的合成。

在此，借助于2,2,2-三氟乙醇和叔丁基溴的组合，建立了2-芳基氨基苯基酮的分子内环化体系，以取代传统的高温，强酸性条件并获得9-取代的a啶。。该方案可以与之前的铜催化的分子间Chan–Evans–Lam交叉偶联反应很好地合并，因此可以在室温下从容易获得的2-氨基苯基酮和芳基硼酸进行锅内经济的模块化合成9-取代的cr啶。