Robert J. Wityk, MD, Associate Professor of Neurology at Johns Hopkins, born June 6, 1959 in Cleveland Ohio, died March 26, 2020 in Timonium, MD of a brain tumor. Bob grew up in Maryland, where he attended Loyola High School. Even in High School, he achieved national recognition as a member of the speech and debate team. He was also the co-founder of The Loyola Gentleman’s Literary Companion, a humor magazine that evolved to a respected literary publication. After winning a nationwide contest for students of German, he traveled to Germany for a month and met his future wife, the former Anne Porter Sommers. He graduated Summa Cum Laude from Yale in 1981, with a BS and MS in Molecular Biophysics and Biochemistry. He completed medical school at Case Western, a residency in Medicine at University of California San Diego and residency in Neurology at Massachusetts General Hospital (MGH). After serving as Chief Resident in Neurology at MGH, he completed a Cerebrovascular Fellowship at Tufts with Louis Caplan, MD. Lou Caplan wrote of his time mentoring Bob from 1991 to 1992, “In his very quiet, methodical, unassuming way he was the central figure in orienting, organizing and mediating among the fellows. He was always very hard-working and responsible. He was well liked and appreciated by the residents and other fellows. He had a wonderful wry sense of humor. After his fellowship he remained very active in studying and interpreting the results of the New England Medical Center Posterior Circulation Registry which was active when he was a fellow.”

Bob joined the faculty of Johns Hopkins in 1992, initially as part-time instructor, and attending neurologist at Sinai Hospital of Baltimore. Initially, along with Barney Stern, MD, Director of the neurology division, Bob expanded stroke services at Sinai, and subsequently became Co-Director of the neurology division together with Brian Litt, MD to elevate the Sinai neurology division to a nationally recognized center ranked by US News and World Report.

Bob came to Johns Hopkins as a full-time faculty member in 1996 to establish a clinical stroke service, training residents and fellows in administration of the newly approved intravenous thrombolysis. He was the first Director of the dedicated inpatient stroke service (1999), the first Director of the Cerebrovascular Division, and initiated the Brain Rescue Unit (BRU) in 2000. He was PI of an NIH funded trial, Induced Hypertension for Acute Ischemic Stroke, and was site PI of several important clinical trials, including the IRIS trial (Insulin Resistance Intervention After Stroke), Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis, and WASID (Warfarin-Aspirin Symptomatic Intracranial Disease Study), which have had important impacts on stroke management. Bob was a respected scholar in the field of stroke, having published over 100 research articles. A few of his most highly cited articles as first or senior author described sex differences in the distribution of cerebral atherosclerosis,¹ longitudinal assessment of acute stroke using the NIHSS,² characteristics of ischemic stroke in the young,³ proximal extracranial vertebral artery disease in the New England Medical Center posterior circulation registry,⁴ and the role of induced hypertension on improving perfusion and function in patients with acute stroke due to large vessel stenosis.⁵ He also made important contributions in understanding how hypoperfusion and reperfusion (measured with magnetic resonance perfusion weighted imagining) affects function in acute stroke,^6–8 after cardiac surgery,⁹ and in transient ischemic attack.¹⁰ Bob also authored many chapters related to clinical stroke in books that serve as reference to the new generations of stroke neurologists and other diverse specialty areas. He also carried out novel research in the areas of stroke due to moya moya disease and the epidemiology of cavernous hemangiomas. Bob was a frequent and thoughtful reviewer for Stroke and other journals in the field.

Bob established a Cerebrovascular Fellowship in 2000 that has had more than 25 graduates, some of whom are working today as professors and associate professors in the field, including Souvik Sen, MD, Professor and Chair of Neurology at University of South Carolina and Rebecca Gottesman, MD, PhD, Professor of Neurology at Johns Hopkins. The ACGME certified the fellowship in 2004. In addition to his exceptional mentoring of residents, fellows, and junior faculty, his outstanding teaching of residents and medical students was recognized by several teaching awards. His educational scholarship extended to co-editing one book on stroke management and lectures on stroke care across the globe. He continued to provide valuable insights and lectures to the stroke journal club at Hopkins until just months before his death.

On a personal level, Bob first began to mentor me when I was a Hopkins medical student, rotating in the Neurology program at Sinai Hospital. He solidified my interest in the rapidly changing field of Stroke and continued to mentor me as a resident, assistant professor with a K23, and throughout my career. Our lengthy discussions of cases and MR images provided a springboard for my research and were among the most rewarding experiences of my professional life. He was always insightful, generous with his time and knowledge, and had a wonderful sense of humor. He is sorely missed by all of our colleagues. Dr Brian Litt, Professor of Neurology and Bio-engineering at the University of Pennsylvania, a colleague at Sinai Hospital for five years after their residencies, said it best: “Bob leaves behind a really impressive legacy. The world is a better place for him having been here.”

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For Sources of Funding and Disclosures, see page 1917.

罗伯特·J·怀蒂克（Robert J.Wityk）医学博士，约翰·霍普金斯大学神经病学副教授，1959年6月6日出生于俄亥俄州克利夫兰，于2020年3月26日去世，死于脑肿瘤的Timonium。鲍勃在马里兰州长大，就读于洛约拉高中。即使在高中时，他还是演讲和辩论小组的成员，也获得了全国认可。他还是幽默杂志《洛约拉绅士文学伴侣》的联合创始人，该杂志后来发展成为备受推崇的文学刊物。在赢得了针对德国学生的全国性比赛之后，他去了德国一个月，遇到了他未来的妻子，前安妮·波特·索默斯。他于1981年从耶鲁大学（Yale）毕业，获得了分子生物学和生物化学学士和硕士学位。他完成了Case Western的医学院，加利福尼亚大学圣地亚哥分校医学专业，麻省总医院（MGH）神经病专业。在MGH担任神经科首席住院医师后，他与马里兰州的路易斯·卡普兰（Louis Caplan）在塔夫茨大学完成了脑血管研究金。卢·卡普兰（Lou Caplan）在1991年至1992年期间曾指导鲍勃（Bob）时写道：“以他非常安静，有条理，谦逊的方式，他是在同伴之间定向，组织和调解的中心人物。他总是非常努力和负责。他深受居民和其他同伴的喜爱和赞赏。他的幽默感极佳。在获得奖学金之后，他仍然非常积极地研究和解释新英格兰医学中心后循环注册系统的结果，该系统在他成为研究员时就很活跃。在MGH担任神经病学首席住院医师后，他与马里兰州的路易斯·卡普兰（Louis Caplan）在塔夫茨大学完成了脑血管研究金。卢·卡普兰（Lou Caplan）在1991年至1992年期间曾指导鲍勃（Bob）时写道：“以他非常安静，有条理，谦逊的方式，他是在同伴之间定向，组织和调解的中心人物。他总是非常努力和负责。他受到居民和其他同伴的喜爱和赞赏。他的幽默感极佳。在获得奖学金之后，他仍然非常积极地研究和解释新英格兰医学中心后循环注册系统的结果，该系统在他成为研究员时就很活跃。在MGH担任神经病学首席住院医师后，他与马里兰州的路易斯·卡普兰（Louis Caplan）在塔夫茨大学完成了脑血管研究金。卢·卡普兰（Lou Caplan）在1991年至1992年期间曾指导鲍勃（Bob）时写道：“以他非常安静，有条理，谦逊的方式，他是在同伴之间定向，组织和调解的中心人物。他总是非常努力和负责。他受到居民和其他同伴的喜爱和赞赏。他的幽默感极佳。在获得奖学金之后，他仍然非常积极地研究和解释新英格兰医学中心后循环注册系统的结果，该系统在他成为研究员时就很活跃。他是有条不紊，谦恭有礼的方式，是在同伴之间定向，组织和调解的中心人物。他总是非常努力和负责。他受到居民和其他同伴的喜爱和赞赏。他的幽默感极佳。在获得奖学金之后，他仍然非常积极地研究和解释新英格兰医学中心后循环注册系统的结果，该系统在他成为研究员时就很活跃。他是有条不紊，谦恭有礼的方式，是在同伴之间定向，组织和调解的中心人物。他总是非常努力和负责。他深受居民和其他同伴的喜爱和赞赏。他的幽默感极佳。在获得奖学金之后，他仍然非常积极地研究和解释新英格兰医学中心后循环注册系统的结果，该系统在他成为研究员时就很活跃。

Bob于1992年加入约翰·霍普金斯大学，最初是兼职讲师，并在巴尔的摩西奈医院主治神经病。最初，鲍勃与神经病学部主任医学博士Barney Stern一起扩大了西奈的中风服务范围，随后与医学博士Brian Litt一起成为神经病学部门的联合主任，将西奈神经病学部门提升为全国公认的中心由美国新闻与世界报道。

鲍勃（Bob）于1996年加入约翰斯·霍普金斯大学（Johns Hopkins），成为一名全职教职员工，以建立临床卒中服务，对居民和其他人员进行新批准的静脉溶栓治疗的管理培训。他是住院中风专用服务的第一任负责人（1999年），脑血管部门的第一任负责人，并于2000年创立了脑部抢救部门（BRU）。他是美国国立卫生研究院（NIH）资助的一项试验，即急性缺血性中风引起的高血压。 ，并且是几个重要临床试验的现场PI，包括IRIS试验（中风后胰岛素抵抗干预），颅内动脉狭窄的支架置入与积极药物治疗以及WASID（华法林-阿司匹林症状性颅内疾病研究），具有重要影响在中风管理上。鲍勃是中风领域受人尊敬的学者，发表了100多篇研究文章。在第一作者或资深作者中，他被引用次数最多的文章描述了脑动脉粥样硬化分布中的性别差异，¹使用NIHSS纵向评估急性卒中，²年轻时缺血性卒中的特征，³新英格兰医学中心后循环注册表中的近端颅外椎动脉疾病，⁴和诱发性高血压在改善患者血流灌注和功能中的作用因大血管狭窄而发生急性中风。⁵，他也理解缺血再灌注（磁共振灌注加权想象衡量）是如何影响急性脑卒中，功能做出了重要贡献^6-8个心脏手术后，⁹和短暂性脑缺血发作。¹⁰鲍勃还在书中撰写了许多与临床中风有关的章节，以作为新一代中风神经病学家和其他不同专业领域的参考。他还在因莫亚莫亚病引起的中风和海绵状血管瘤的流行病学领域进行了新颖的研究。鲍勃（Bob）是Stroke和该领域其他期刊的频繁而周到的审稿人。

鲍勃（Bob）于2000年建立了脑血管研究金计划，目前已有25多名毕业生，其中一些人目前是该领域的教授和副教授，其中包括南卡罗来纳大学和神经病学教授Souvik Sen，医学博士和Rebecca Gottesman，医学博士，约翰霍普金斯大学神经病学教授。ACGME于2004年认证了该研究金。除了他对居民，研究员和初级教师的出色指导外，他对居民和医学生的杰出教学也获得了多个教学奖的认可。他的教育奖学金扩展到在全球共同编辑一本有关中风管理的书和中风保健讲座。直到去世前几个月，他一直为霍普金斯中风期刊俱乐部提供有价值的见解和演讲。

就个人而言，当我还是霍普金斯大学医学院的学生时，鲍勃首先开始指导我，当时他在西奈医院的神经病学专业任职。他巩固了我对快速变化的Stroke领域的兴趣，并继续指导我担任K23的住院医师，助理教授，并贯穿了我的整个职业生涯。我们对案件和MR图像的冗长讨论为我的研究提供了跳板，并且是我职业生涯中最有意义的经历之一。他总是富有洞察力，慷慨的时间和知识以及幽默感。我们所有的同事都非常想念他。宾夕法尼亚大学神经病学和生物工程学教授布莱恩·利特（Brian Litt）博士在西奈医院任职五年后一直是同事。

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有关资金和披露的来源，请参阅第1917页。