Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian Aspergillus flavipes.,Journal of Natural Products

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Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian Aspergillus flavipes.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2020-06-22 , DOI: 10.1021/acs.jnatprod.0c00344
Cong Wang _{1,

2} , Xiaohua Wu ₁ , Helong Bai _{1,

3} , Kh Ahammad Uz Zaman ₁ , Shaobin Hou ₄ , Jennifer Saito ₄ , Supakit Wongwiwatthananukit ₁ , Kyung Sik Kim ₅ , Shugeng Cao ₁

Affiliation

Five new lumazine peptides (1–5), a new aspochalasin derivative (6), and a new γ-butyrolactone derivative (7), together with seven known compounds (8–14), were isolated from a Hawaiian fungal strain, Aspergillus flavipes FS888. Compound 1 is an uncommon natural product containing an isocyano group. The structures of the new compounds 1–7 were elucidated by NMR spectroscopy, HRESIMS, chemical derivatization, and ECD analysis. Compounds 12–14 showed significant antibacterial activity against S. aureus when in combination with disulfiram. Additionally, compounds 9 and 13 showed NF-κB inhibitory activity with IC₅₀ values of 3.1 ± 1.0 and 10.3 ± 2.0 μM, respectively.

中文翻译：

来自夏威夷黄曲霉的抗菌和 NF-κB 抑制性 Lumazine 肽、Aspochalasin、γ-丁内酯衍生物和环状肽。

从夏威夷真菌菌株黄曲霉中分离出五种新的 lumazine 肽 ( 1 – 5 )、一种新的 aspochalasin 衍生物 ( 6 ) 和一种新的 γ-丁内酯衍生物 ( 7 ) 以及七种已知化合物 ( 8 – 14 ) FS888。化合物1是一种罕见的天然产物，含有异氰基。新化合物的结构1 - 7通过NMR光谱学，HRESIMS，化学衍生化，和ECD分析阐明。化合物12 - 14显示显著抗菌活性对金黄色葡萄球菌与双硫仑合用时。此外，化合物9和13显示出 NF-κB 抑制活性，IC ₅₀值分别为 3.1 ± 1.0 和 10.3 ± 2.0 μM。

更新日期：2020-07-24

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