Cell metabolism can be defined as the anabolic and catabolic biochemical pathways that generate energy, supply building blocks for synthesis and enable the breakdown of complex molecules. Vast efforts have succeeded in delineating these processes in a huge number of cell types across the entire range of species. Many basic pathways are in fact shared across this range and by all cells within individuals. Understanding this platform has allowed context-dependent and function-defining differences to be investigated and characterized, with the potential for translational research and therapeutic manipulation. This is of course true for the cells of the immune system through their various stages of differentiation and activation in health and disease. Immunometabolism has benefitted both from our understanding of the fundamentals of metabolism and from the many newly available research and analytical methods that can be utilized. As with other aspects of the immune system, responses are the result of a complex interplay of intracellular and extracellular metabolites from different immune cell types as well as the microbiota, infections and cancer cells. This Special Issue, which comprises six review articles, aims to give an up-to-date synthesis of insights about the immune system that have been provided by the relatively new but already fascinating field of immunometabolism.

中文翻译：

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简介：特刊-免疫代谢

细胞代谢可定义为合成代谢和分解代谢生化途径，它们产生能量，为合成提供基础，并使复杂分子分解。大量的努力成功地在整个物种范围内的大量细胞类型中描绘了这些过程。实际上，许多基本途径在该范围内以及个体内的所有细胞都共享。了解此平台后，就可以对上下文相关和功能定义方面的差异进行调查和表征，并具有进行翻译研究和治疗操作的潜力。免疫系统的细胞在健康和疾病中的分化和激活的各个阶段当然是正确的。免疫代谢既受益于我们对代谢基本原理的理解，也受益于许多新近可用的研究和分析方法。与免疫系统的其他方面一样，应答是来自不同免疫细胞类型以及微生物群，感染和癌细胞的细胞内和细胞外代谢物复杂相互作用的结果。本期特刊由六篇评论文章组成，旨在提供有关免疫系统的最新见解，这些见解是由相对较新但已十分有趣的免疫代谢领域提供的。应答是来自不同免疫细胞类型以及微生物群，感染和癌细胞的细胞内和细胞外代谢物复杂相互作用的结果。本期特刊由六篇评论文章组成，旨在提供有关免疫系统的最新见解，这些见解是由相对较新但已十分有趣的免疫代谢领域提供的。应答是来自不同免疫细胞类型以及微生物群，感染和癌细胞的细胞内和细胞外代谢物复杂相互作用的结果。本期特刊由六篇评论文章组成，旨在提供有关免疫系统的最新见解，这些见解是由相对较新但已十分有趣的免疫代谢领域提供的。