Abstract

Background

During HIV retesting in antenatal and preexposure prophylaxis (PrEP) care, discrepant results occur, but guidelines are lacking.

Methods

In a Kenyan trial implementing antenatal PrEP, if 1 test is reactive, a second is performed; if discrepant, both are repeated; if persistently discrepant, DNA polymerase chain reaction (PCR) is performed.

Results

Among 4451 women, 23 265 HIV retesting sessions were performed; 14 (0.06%, 95% confidence interval, 0.03%–0.10%) had discrepant results among 10 individuals; in all 10 initial cases, PCR was negative.

Conclusions

Discrepant rapid tests are an expected, rare, and important challenge for antenatal care HIV retesting, with and without PrEP.

Clinical Trials Registration

NCT03070600.

中文翻译：

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PrEP 时代孕妇 HIV 检测不一致的挑战——治疗还是不治疗？

摘要

背景

在产前和暴露前预防 (PrEP) 护理中重新检测 HIV 期间，会出现不一致的结果，但缺乏指导方针。

方法

在肯尼亚实施产前 PrEP 的试验中，如果 1 个测试是反应性的，则执行第二个；如果不一致，则重复两者；如果持续不一致，则进行 DNA 聚合酶链反应 (PCR)。

结果

在 4451 名妇女中，进行了 23265 次艾滋病毒复检；14 人（0.06%，95% 置信区间，0.03%–0.10%）在 10 个人中的结果存在差异；在所有 10 个初始病例中，PCR 均为阴性。

结论

有差异的快速检测对于产前护理 HIV 重新检测而言是预期的、罕见的和重要的挑战，无论是否使用 PrEP。

临床试验注册

NCT03070600。