This minireview considers the disruption of the host-microbiota harmless symbiosis in the subgingival niche. The establishment of a chronic infection by subversion of a commensal microbiota results from a complex and multiparametric sequence of events. This review narrows down to the interplay between oxygen, iron and sulfide that can result in a vicious cycle that would favour peroxigenic and glutathione producing streptococci as well as sulfidogenic anaerobic pathogens in the subgingival niche. We propose hypothesis and discuss strategies for the therapeutic modulation of the microbiota to prevent periodontitis and promote oral health.

中文翻译：

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可能导致龈下菌群失调的事件：关注铁、硫化物和氧之间的相互作用。

这篇小综述考虑了龈下生态位中宿主-微生物群无害共生的破坏。通过破坏共生微生物群来建立慢性感染是由复杂的多参数事件序列造成的。这篇综述将范围缩小到氧、铁和硫化物之间的相互作用，这可能导致恶性循环，有利于产生过氧和谷胱甘肽的链球菌以及龈下生态位中的硫化厌氧病原体。我们提出假设并讨论微生物群的治疗调节策略，以预防牙周炎和促进口腔健康。