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HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2020-06-22 , DOI: 10.1146/annurev-biochem-011520-102754
Zakia Djaoud 1 , Peter Parham 1
Affiliation  

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and take it to the cell surface for surveillance by lymphocytes. These include natural killer (NK) cells and γδ T cells of innate immunity and αβ T cells of adaptive immunity. In healthy cells, the presented peptides derive from human proteins, to which lymphocytes are tolerant. In pathogen-infected cells, HLA class I expression is perturbed. Reduced HLA class I expression is detected by KIR and CD94:NKG2A receptors of NK cells. Almost any change in peptide presentation can be detected by αβ CD8+ T cells. In responding to extracellular pathogens, HLA class II glycoproteins, expressed by specialized antigen-presenting cells, present peptides to αβ CD4+ T cells. In comparison to the families of major histocompatibility complex (MHC) class I, MHC class II and αβ T cell receptors, the antigenic specificity of the γδ T cell receptors is incompletely understood.

中文翻译:


HLA,TCR和KIR(人类细胞介导的免疫的Triumvirate)。

在所有人类细胞中,人类白细胞抗原(HLA)I类糖蛋白与肽组装在一起,并将其带到细胞表面,以供淋巴细胞监视。这些包括先天免疫的自然杀伤(NK)细胞和γδT细胞,以及适应性免疫的αβT细胞。在健康细胞中,所呈递的肽源于人类蛋白,淋巴细胞对此具有耐受性。在感染病原体的细胞中,HLA I类表达受到干扰。NK细胞的KIR和CD94:NKG2A受体检测到HLA I类表达降低。肽呈递的几乎任何变化都可以通过αβCD8 + T细胞检测到。在应对细胞外病原体时,由专门的抗原呈递细胞表达的HLA II类糖蛋白将肽呈递给αβCD4 +T细胞。与主要的组织相容性复合体(MHC)I类,MHC II类和αβT细胞受体家族相比,对γδT细胞受体的抗原特异性尚不完全了解。

更新日期:2020-06-23
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