Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2020-06-22 , DOI: 10.1146/annurev-biochem-011520-104722 David P Waterman 1 , James E Haber 1 , Marcus B Smolka 2
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
中文翻译:
检查点对 DNA 双链断裂的反应。
细胞在每个细胞周期都会面临 DNA 损伤。最有害的 DNA 损伤类型是 DNA 双链断裂 (DSB),如果未修复,可能会导致细胞死亡,如果修复不当,可能会导致癌症。为了响应 DNA DSB,细胞激活复杂的 DNA 损伤检查点 (DDC) 反应,该反应会阻止细胞周期、重新编程基因表达并调动 DNA 修复因子以防止未修复和断裂染色体的遗传。在这里,我们检查了芽殖酵母模型系统和哺乳动物中由 DNA DSB 诱导的 DDC。