The pre-metastatic niche is a complex microenvironment formed by the influence of tumor-derived factors on stromal and immune cells at distant sites of disseminated tumor-cell colonization. Signaling through the kinase p38α and regulation of the type I interferon receptor are now linked to formation of the pre-metastatic niche.

中文翻译：

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映射驱动转移前利基的开关

转移前生态位是一个复杂的微环境，由肿瘤衍生因子对远处播散性肿瘤细胞定植部位的基质和免疫细胞的影响而形成。通过激酶 p38α 的信号传导和 I 型干扰素受体的调节现在与转移前生态位的形成有关。