Abstract

A novel antioxidant glutathione liposomes (GSH-LIP) were prepared and applied for diabetic nephropathy therapy. GSH-LIP not only improve the bioavailability and antioxidant capacity of glutathione to scavenge redundant ROS inducing by oxidative stress, but also effectively inhibit the activity of AR and sorbitol accumulation in polyol pathway. The imaging in vivo showed that GSH-LIP could target kidney and significantly improve renal pathology. GSH-LIP may become a new AR inhibitor and antioxidant, which provides a new theoretical basis for the study of drugs for therapy diabetic nephropathy.

中文翻译：

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基于氧化应激和多元醇通路机制的谷胱甘肽脂质体对糖尿病肾病的影响

摘要

制备了一种新型抗氧化谷胱甘肽脂质体（GSH-LIP）并应用于糖尿病肾病的治疗。GSH-LIP不仅能提高谷胱甘肽的生物利用度和抗氧化能力，清除氧化应激诱导的多余ROS，还能有效抑制AR活性和山梨糖醇在多元醇途径中的积累。体内成像显示GSH-LIP可以靶向肾脏并显着改善肾脏病理。GSH-LIP可能成为一种新的AR抑制剂和抗氧化剂，为糖尿病肾病治疗药物的研究提供了新的理论基础。