ABSTRACT

Introduction

In the current era of relatively scarce antibiotic production and significant levels of antimicrobial resistance, optimization of pharmacokinetics and pharmacodynamics of antibiotic therapy is mandatory. Prolonged infusion of beta-lactam antibiotics in comparison to the intermittent infusion has the theoretical advantage of better patient outcomes. Apparently, conflicting data in the literature possibly underestimate the benefits of prolonged infusion of antibiotic treatment.

Areas covered

We provide our perspective on the subject based on our experience and by critically evaluating literature data.

Expert opinion commentary

In our opinion, the available data are suggestive of the beneficial role of prolonged infusion of beta-lactams in regard to piperacillin/tazobactam and carbapenems after administering a loading dose. While more data from randomized controlled trials are necessary to solidify or negate the evident benefits of prolonged infusion of the aforementioned antibiotics, clinicians should strongly consider this mode of administration of relevant antibiotics, especially in patients with severe infections.

中文翻译：

---

败血症患者长期输注β-内酰胺类抗生素的益处：个人观点。

摘要

介绍

在当前抗生素生产相对稀缺且抗微生物剂水平显着水平的时代，必须优化抗生素疗法的药代动力学和药效学。与间歇性输注相比，长时间输注β-内酰胺类抗生素具有更好的患者预后的理论优势。显然，文献中相互矛盾的数据可能低估了长期输注抗生素治疗的益处。

覆盖区域

我们将根据我们的经验并通过严格评估文献数据来提供关于该主题的观点。

专家意见评论

我们认为，现有数据表明，在给予负荷剂量后，长期输注β-内酰胺对哌拉西林/他唑巴坦和碳青霉烯类药物具有有益作用。虽然有必要从随机对照试验中获得更多数据，以巩固或消除长期输注上述抗生素的明显益处，但临床医生应强烈考虑相关抗生素的这种给药方式，尤其是在严重感染患者中。