Abstract

Nanoparticles with unique properties have potential applications in food, medicine, pharmacology, and agriculture industries. Accordingly, many significant researches have been conducted to develop novel nanoparticles using chemical and biological techniques. This review focuses on the synthesis of selenium nanoparticles (SeNPs) using polysaccharides as templates. Various instrumental techniques being used to confirm the formation of polysaccharide-SeNPs conjugates and characterize the properties of nanoparticles are also introduced. Finally, the biological activities of the synthesized SeNPs and the influence of structural factors of polysaccharides on the property of synthetic nanocomposites are highlighted. In general, the polysaccharides functionalized SeNPs can be easily obtained using sodium selenite as precursor and ascorbic acid as reductant. The final products having different particle size, morphology, and selenium content exhibit abundant physiological activities. Structural factors of polysacchairdes involving molecular weights, substitution of functional groups, and chain conformation play determinant roles on the properties of nanocomposites, resulting in different biological performances. The review on the achievements and current status of polysaccharides conjugated SeNPs provides insights into this exciting research topic for further studies in the future.

摘要

具有独特性质的纳米粒子在食品、医药、药理学和农业等行业具有潜在的应用价值。因此，已经进行了许多重要的研究以使用化学和生物技术开发新型纳米粒子。本综述侧重于使用多糖作为模板合成硒纳米粒子 (SeNPs)。还介绍了用于确认多糖-SeNPs 共轭物的形成和表征纳米粒子特性的各种仪器技术。最后，强调了合成的SeNPs的生物活性和多糖结构因素对合成纳米复合材料性能的影响。一般来说，使用亚硒酸钠作为前体和抗坏血酸作为还原剂可以很容易地获得多糖功能化的 SeNP。具有不同粒径、形态和硒含量的最终产品表现出丰富的生理活性。多糖的结构因素包括分子量、官能团取代和链构象对纳米复合材料的性能起着决定性作用，导致不同的生物性能。对多糖缀合 SeNP 的成就和现状的回顾为未来的进一步研究提供了对这一令人兴奋的研究课题的见解。官能团的取代和链构象对纳米复合材料的性能起着决定性作用，导致不同的生物学性能。对多糖缀合 SeNP 的成就和现状的回顾为未来的进一步研究提供了对这一令人兴奋的研究课题的见解。官能团的取代和链构象对纳米复合材料的性能起着决定性作用，导致不同的生物学性能。对多糖缀合 SeNP 的成就和现状的回顾为未来的进一步研究提供了对这一令人兴奋的研究课题的见解。