Abstract

Many studies have reported hemocytometric changes in COVID-19 infection at admission and during the course of disease, but an overview is lacking. We provide a summary of the literature of hemocytometric changes and evaluate whether these changes may assist clinicians in diagnosing and predicting disease progression of COVID-19. Eighty-three out of 250 articles from December 2019 to 20 May 2020 were included from the databases, PubMed, Web of Science Core Collection, Embase, Cochrane and MedRxiv. Our review of the literature indicates that lymphopenia and an elevated neutrophil/lymphocyte ratio are the most consistent abnormal hemocytometric findings and that these alterations may augment in the course of time, especially in those with severe disease.

摘要

许多研究报告了入院时和疾病过程中COVID-19感染的血细胞计数变化，但缺乏概述。我们提供了有关血细胞计数变化的文献的摘要，并评估了这些变化是否可以帮助临床医生诊断和预测COVID-19的疾病进展。从2019年12月至2020年5月20日的250篇文章中，有83篇来自数据库PubMed，Web of Science核心合集，Embase，Cochrane和MedRxiv。我们对文献的审查表明，淋巴细胞减少症和嗜中性粒细胞/淋巴细胞比例升高是最一致的异常血细胞计数发现，并且这些改变可能会随着时间的推移而增加，尤其是在那些患有严重疾病的患者中。