Preamble Polymer-drug conjugates have been intensively investigated for several decades, and even though their clinical success still lags behind the promise many researchers have placed in them, they are a mainstay in the fields of polymer therapeutics or nanomedicine. For many in the field, the seminal perspective paper by Helmut Ringsdorf from 1975 marks the beginning of this field of research. With more than one thousand citations, this paper has indubitably affected and inspired generations of researchers in the field, including the author of this translation. However, it is not the first paper describing the concept of polymer-drug conjugates. Some twenty years earlier, Horst Jatzkewitz described in two outstanding articles probably the historically first polymer-drug conjugates, detailed its synthesis, characterization and even first in vivo experiments. The results, carefully re-interpreted through the eyes of a scientist of the 21st century, clearly highlight several issues that need to be taken into consideration when designing polymer-drug conjugates. However, despite the pioneering nature of this paper, it is all but forgotten by the scientific community. In the author’s opinion, Horst Jatzkewitz and these papers clearly did not receive the attention and praise they deserve. Whether this was because these paper were much ahead of it´s time, or because it was published in German language, or for some other reason, we cannot know. However, these papers are, in my opinion, an excellent piece of work that should be known more widely and available to students and experts world-wide, which is why the author decided to translate it. Also, to give some more context and to help understand some outdated terms or concepts, additional comments and explanations are added throughout. I hope that this will help for these papers to receive the attention I believe they deserve.

中文翻译：

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历史上第一个聚合物药物偶联物的描述及其体内评估的教程翻译

前言 聚合物-药物偶联物已被深入研究了几十年，尽管它们的临床成功仍落后于许多研究人员对其的承诺，但它们是聚合物疗法或纳米医学领域的中流砥柱。对于该领域的许多人来说，Helmut Ringsdorf 于 1975 年发表的开创性透视论文标志着这一研究领域的开始。这篇论文被引用超过一千次，无疑影响和启发了该领域的几代研究人员，包括本译本的作者。然而，这并不是第一篇描述聚合物-药物偶联物概念的论文。大约二十年前，Horst Jatzkewitz 在两篇杰出的文章中描述了可能是历史上第一个聚合物-药物偶联物，详细介绍了它的合成，表征，甚至首次进行体内实验。结果，通过 21 世纪科学家的眼睛仔细重新解释，清楚地突出了在设计聚合物-药物偶联物时需要考虑的几个问题。然而，尽管这篇论文具有开创性，但它几乎被科学界所遗忘。在作者看来，Horst Jatzkewitz 和这些论文显然没有得到应有的关注和赞扬。这是因为这些论文远远领先于它的时代，还是因为它是用德语发表的，或者是其他什么原因，我们无法知道。然而，在我看来，这些论文是一部优秀的作品，应该被更广泛地了解并为世界各地的学生和专家提供，这就是作者决定翻译它的原因。还，为了提供更多上下文并帮助理解一些过时的术语或概念，在整个过程中添加了额外的评论和解释。我希望这将有助于这些论文得到我认为它们应得的关注。