Abstract Fraxinellone is a naturally occurring degraded limonoid isolated from many species of plants in Meliaceae and Rutaceae. Besides structural modification of the lead compounds, the toxicology study of the lead compounds is also a very important procedure to develop insecticidal agents. Herein the toxicology study of fraxinellone was carried out as the ovicidal agent against the eggs of two lepidopteran insects Mythimna separata Walker and Bombyx mori Linaeus. Fraxinellone selectively exhibited an ovicidal activity against the eggs of M. separata. After treatment with fraxinellone, the eggshells of M. separata were shrinked, whereas those of B. mori had no obvious change. The dynamic process of M. separata embryo development demonstrated that the distinct difference between the treated eggs and the control ones was obvious at the second day after treatment, especially, the control embryo finished blastokinesis, whereas the treated ones were still laid at pre-reversion status and a lot of yolk can be seen around the embryo. It ultimately resulted in the eggshell withered and the egg hatching inhibited.

中文翻译：

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弗拉辛酮作为杀卵剂对 Mythimna separata Walker 和 Bomboyx mori Linaeus 的毒理学研究

摘要 Fraxinellone 是一种天然降解的柠檬苦素类化合物，从楝科和芸香科的许多植物中分离出来。除了先导化合物的结构修饰外，先导化合物的毒理学研究也是开发杀虫剂的一个非常重要的过程。在本文中，弗拉辛酮作为杀卵剂对两种鳞翅目昆虫 Mythimna separata Walker 和 Bombyx mori Linaeus 的卵进行毒理学研究。Fraxinellone 选择性地对 M. separata 的卵表现出杀卵活性。用fraxinellone处理后，M. separata的蛋壳缩小，而B. mori的蛋壳没有明显变化。M的动态过程 分离胚胎发育表明，处理后第2天，处理卵与对照的差异明显，尤其是对照胚胎完成了胚泡发育，而处理卵仍处于倒转前状态和大量卵黄。可以看到胚胎周围。最终导致蛋壳枯萎，卵孵化受阻。