Thietanes are important aliphatic four-membered thiaheterocycles that are found in the pharmaceutical core and structural motifs of some biological compounds. They are also useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed, including inter- and intramolecular nucleophilic thioetherifications, photochemical [2 + 2] cycloadditions, ring expansions and contractions, nucleophilic cyclizations, and some miscellaneous methods. The recently developed methods provide some new strategies for the efficient preparation of thietanes and their derivatives. This review focuses on the synthetic methods to construct thietane backbones developed during 1966 to 2019.

中文翻译：

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硫杂环丁烷的最新合成。

硫杂环丁烷是重要的脂肪族四元硫杂环化合物，存在于某些生物化合物的药物核心和结构图案中。它们也是有机合成中有用的中间体。已经开发了各种硫杂环丁烷的合成方法，包括分子间和分子内亲核硫醚化，光化学[2 + 2]环加成，环膨胀和收缩，亲核环化以及一些其他方法。最近开发的方法为有效制备硫杂环丁烷及其衍生物提供了一些新策略。这篇综述着重于构建从1966年到2019年开发的硫杂环丁烷骨架的合成方法。