Restriction point regulation at the crossroads between quiescence and cell proliferation,FEBS Letters

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Restriction point regulation at the crossroads between quiescence and cell proliferation
FEBS Letters ( IF 3.0 ) Pub Date : 2020-07-01 , DOI: 10.1002/1873-3468.13867
Betheney R Pennycook _{1,

2} , Alexis R Barr _{1,

2}

Affiliation

The coordination of cell proliferation with reversible cell cycle exit into quiescence is crucial for the development of multicellular organisms and for tissue homeostasis in the adult. The decision between quiescence and proliferation occurs at the restriction point, which is widely thought to be located in the G1 phase of the cell cycle, when cells integrate accumulated extracellular and intracellular signals to drive this binary cellular decision. On the molecular level, decision‐making is exerted through the activation of cyclin‐dependent kinases (CDKs). CDKs phosphorylate the retinoblastoma (Rb) transcriptional repressor to regulate the expression of cell cycle genes. Recently, the classical view of restriction point regulation has been challenged. Here, we review the latest findings on the activation of CDKs, Rb phosphorylation and the nature and position of the restriction point within the cell cycle.

中文翻译：

静止和细胞增殖十字路口的限制点调节

细胞增殖与可逆细胞周期进入静止状态的协调对于多细胞生物的发育和成人的组织稳态至关重要。静止和增殖之间的决定发生在限制点，人们普遍认为该限制点位于细胞周期的 G1 期，此时细胞整合积累的细胞外和细胞内信号来驱动这种二元细胞决定。在分子水平上，决策是通过细胞周期蛋白依赖性激酶（CDK）的激活来发挥的。 CDK 磷酸化视网膜母细胞瘤 (Rb) 转录抑制因子以调节细胞周期基因的表达。最近，限制点调节的经典观点受到了挑战。在此，我们回顾了有关 CDK 激活、Rb 磷酸化以及细胞周期内限制点的性质和位置的最新研究结果。

更新日期：2020-07-01

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