Vascular morphology and expression of angiogenic factors in sheep ovaries and their relation with the lambing rate.,Reproduction in Domestic Animals

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Vascular morphology and expression of angiogenic factors in sheep ovaries and their relation with the lambing rate.
Reproduction in Domestic Animals ( IF 1.7 ) Pub Date : 2020-06-21 , DOI: 10.1111/rda.13751
Xinrong Wang ₁ , Yanan Yang ₁ , Mingna Li ₁

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The study aims to present the vascular anatomy of ovarian arterial system in sheep and to explore its relation with the angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin‐2 (Ang‐2), environmental factors and the lambing rate. Small‐tailed Han sheep, Hu sheep, Aohan finewool sheep and Tibetan sheep who are from different habitats in China and with different lambing rates were investigated. The vascular corrosion casting technique and scanning electron microscopy were used to understand arterial architecture, and real‐time quantitative PCR (qRT‐PCR) and Western blotting were used for assessing VEGF and Ang‐2 expression. Results showed that high‐prolificity breeds had significantly larger vessel diameters in ovaries than low‐prolificity ones. VEGF gene transcript and protein expression were related with the lambing rate, while Ang‐2 gene transcript was negatively related with the lambing rate. Results indicated that high‐prolificity breeds have more abundant arterial blood supply, which is associated with VEGF expression.

更新日期：2020-06-21

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