An unusual detection of tert-butyl-4-anilinopiperidine-1-carboxylate in seizures of falsified 'Xanax' tablets and in items in a suspected heroin seizure submitted by Irish law enforcement.,Drug Testing and Analysis

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An unusual detection of tert-butyl-4-anilinopiperidine-1-carboxylate in seizures of falsified 'Xanax' tablets and in items in a suspected heroin seizure submitted by Irish law enforcement.
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2020-07-15 , DOI: 10.1002/dta.2884
Colette May ₁ , Carol Downey ₁ , John D Power ₁ , Pierce V Kavanagh ₂

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The identification of tert‐butyl‐4‐anilinopiperidine‐1‐carboxylate (4‐anilinopiperdine‐t‐BOC or 4‐AP‐t‐BOC) in many seized falsified ‘Xanax’ tablets has been reported after being encountered in forensic casework in late 2019 and early 2020 in Ireland. This substance was also detected in a pink powder submitted for analysis in March 2020. The pink powder was part of a larger seizure comprising brown powders which contained morphine or diamorphine (heroin) or a type of counterfeit heroin or heroin adulterant (known as ‘bash’). Novel benzodiazepines and other substances are being detected as ingredients in falsified benzodiazepine tablets more frequently on the illicit market. The detection of 4‐AP‐t‐BOC in benzodiazepine tablets is noteworthy and 4‐AP‐t‐BOC is added to the list of adulterants found in benzodiazepine tablets emerging in Europe. The presence of 4‐AP‐t‐BOC in both falsified ‘Xanax’ and powdered seizures is unusual, and analytical data are presented to assist with the identification of this compound in suspected illicit substances. The presence of 4‐AP‐t‐BOC in the tablets was confirmed using gas chromatography–mass spectrometry and liquid chromatography–mass spectrometry analyses, and spectral fragmentation pathways were suggested. To the authors' best knowledge, information about the biological activity of 4‐AP‐t‐BOC is not available. The removal of the t‐BOC protecting group yields 4‐anilinopiperidine which has been reported to be involved in the synthesis of fentanyl.

中文翻译：

在爱尔兰执法部门提交的缉获的伪造“Xanax”药片和涉嫌海洛因缉获的物品中，不寻常地检测到叔丁基 4-苯胺哌啶 1-羧酸酯。

据报道，在最近的法医案件中发现了许多缉获的伪造“Xanax”片剂中的叔丁基-4-苯胺哌啶-1-羧酸酯（4-苯胺哌啶-t - BOC 或 4-AP- t - BOC） 2019 年和 2020 年初在爱尔兰。在 2020 年 3 月提交分析的粉红色粉末中也检测到了这种物质。粉红色粉末是更大缉获量的一部分，其中包含含有吗啡或二吗啡（海洛因）或一种假冒海洛因或海洛因掺杂物（称为“bash”）的棕色粉末'）。新型苯二氮卓类和其他物质在非法市场上更频繁地被检测为伪造的苯二氮卓类药片中的成分。4-AP- t的检测苯二氮卓片中的-BOC 值得注意，4-AP- t - BOC 被添加到欧洲新出现的苯二氮卓片中发现的掺杂物清单中。在伪造的“Xanax”和粉末缉获物中都存在 4-AP- t - BOC 是不寻常的，并且提供了分析数据以帮助在可疑的非法物质中识别该化合物。使用气相色谱-质谱和液相色谱-质谱分析证实了片剂中 4-AP- t -BOC 的存在，并提出了光谱碎片途径。据作者所知，关于 4-AP- t -BOC 生物活性的信息尚不可用。t-的去除BOC 保护基团产生 4-苯胺基哌啶，据报道其参与芬太尼的合成。

更新日期：2020-07-15

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