DMAP‐Catalyzed C—N Bond Formation for Diverse Synthesis of Imidazo[1,2‐a]pyrimidine and Pyrimido[1,2‐a]benzimidazole Derivatives,Chinese Journal of Chemistry

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DMAP‐Catalyzed C—N Bond Formation for Diverse Synthesis of Imidazo[1,2‐a]pyrimidine and Pyrimido[1,2‐a]benzimidazole Derivatives
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-06-21 , DOI: 10.1002/cjoc.202000214
Le‐Le Shang ₁ , Yun Feng ₁ , Xing‐Lian Gao ₁ , Zi‐Ren Chen ₁ , Yu Xia ₁ , Wei‐Wei Jin ₁ , Chen‐Jiang Liu ₁

Affiliation

A DMAP (2‐dimethylaminopyridine)‐catalyzed condensation reactions for the successful direct construction of pyrimido[1,2‐a]benzimidazole or imidazo[1,2‐a]pyrimidine has been developed. The method utilizes readily available α‐bromocinnamaldehydes with 2‐aminobenzimidazole or 2‐aminoimidazole as starting materials in the presence of 2‐DMAP/TBHP. In the process, two C—N bonds were successfully constructed to synthesize target compounds. The current method features wide substrate scope, product diversification, and metal‐free conditions.

中文翻译：

DMAP催化的CN键形成，可合成咪唑并[1,2-a]嘧啶和嘧啶基[1,2-a]苯并咪唑衍生物

甲DMAP（2-二甲基氨基）嘧啶并用于的成功直接施工催化的缩合反应[1,2一]苯并咪唑或咪唑并[1,2一]嘧啶已经研制成功。该方法在2-DMAP / TBHP存在的情况下利用现成的α-溴肉桂醛与2-氨基苯并咪唑或2-氨基咪唑为起始原料。在此过程中，成功构建了两个CN键以合成目标化合物。当前的方法具有广泛的基材范围，产品多样化和无金属条件。

更新日期：2020-06-21

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