Pathway attenuation of fatty acid beta-oxidation in the skeletal muscle of a type 2 diabetic mouse model.,Rapid Communications in Mass Spectrometry

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Pathway attenuation of fatty acid beta-oxidation in the skeletal muscle of a type 2 diabetic mouse model.
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-06-20 , DOI: 10.1002/rcm.8869
Yang Zhou _{1,

2} , Yifan Tan _{1,

2} , Guixue Hou _{1,

2} , Yan Ren _{1,

2} , Yamei Deng _{1,

2} , Keqiang Yan _{1,

2} , Yue Zhang _{1,

2} , Liang Lin _{1,

2} , Xiaomin Lou ₃ , Siqi Liu _{1,

2}

Affiliation

Whether catabolic abnormalities of fatty acids exist in the skeletal muscle of type 2 diabetes mellitus (T2DM) has not been determined. In this study, we postulated that a systematic evaluation of the protein abundance and metabolic activity related to fatty acids in the skeletal muscle tissues of a T2DM mouse model was feasible to address this question.

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