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Multiple Hydrogen Bonds-Reinforced Hydrogels with High Strength, Shape Memory, and Adsorption Anti-Inflammatory Molecules.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-06-22 , DOI: 10.1002/marc.202000202 Xuefeng Li 1, 2 , Xueyin Peng 1 , Rongzhe Li 1 , Yikun Zhang 1 , Zuifang Liu 2 , Yiwan Huang 1 , Shijun Long 2 , Haiyan Li 3
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-06-22 , DOI: 10.1002/marc.202000202 Xuefeng Li 1, 2 , Xueyin Peng 1 , Rongzhe Li 1 , Yikun Zhang 1 , Zuifang Liu 2 , Yiwan Huang 1 , Shijun Long 2 , Haiyan Li 3
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The research on multiple hydrogen bonds (H‐bonds) hydrogels have gradually aroused wide interest. In this paper, a multiple H‐bonds‐reinforced poly(acrylamide‐co‐2‐vinyl‐4,6‐diamino‐2‐vinyl‐1,3,5‐triazine)/tannic acid (P(Am‐co‐VDT)/TA) hydrogels are prepared. The results suggest that the prepared hydrogel has two types of H‐bonds crosslinking regions: A “soft” region of H‐bonds between the diaminotriazine (DAT) moieties on the polymer chains and the TA pyrogallol/catechol groups, and a “hard” region of H‐bonds forming by DAT moieties with itself. The hard crosslinking region exhibits significantly higher activation energy than the soft region. Such soft and hard dual physically crosslinked networks dramatically enhance the mechanical properties of P(Am‐co‐VDT)/TA hydrogels in a synergistic manner (tensile strength is 2.34 MPa, elongation at break is 410%). Due to the multiple hydrogen bonds, the hydrogel has good pH sensitivity and rapid response to shape memory within a few minutes. In addition, the hydrogels have the capacity of physical adsorption of the anti‐inflammatory drug diclofenac sodium and other molecules with a specific spatially arranged chemical composition. These hydrogels with high mechanical strength, excellent shape memory behavior, and capacity of adsorption of anti‐inflammatory drug could be attractive candidates for applications in the fields of biomedicine, tissue engineering, and medical materials.
中文翻译：
具有高强度，形状记忆和吸附抗炎分子的多重氢键增强水凝胶。
对多种氢键（H键）水凝胶的研究逐渐引起了广泛的兴趣。在本文中，多氢键增强的聚（丙烯酰胺-共-2-乙烯基-4,6-二氨基-2-乙烯基-1,3,5-三嗪）/单宁酸（P（AM- CO -VDT制备）/ TA）水凝胶。结果表明，制备的水凝胶具有两种类型的H键交联区域：聚合物链上的二氨基三嗪（DAT）部分和TA邻苯三酚/邻苯二酚基团之间的H键“软”区域，以及“硬”区域DAT部分与其自身形成的H键区域。硬交联区显示出比软区高得多的活化能。这样的软，硬双物理交联的网络极大地提高P的机械特性（AM- CO-VDT）/ TA水凝胶的协同作用（抗张强度为2.34 MPa，断裂伸长率为410％）。由于存在多个氢键，因此水凝胶在几分钟内具有良好的pH敏感性和对形状记忆的快速响应。此外，水凝胶还具有物理吸附抗炎药双氯芬酸钠和其他具有特定空间排列化学成分的分子的能力。这些具有高机械强度，出色的形状记忆行为和抗炎药吸附能力的水凝胶可能是在生物医学，组织工程和医疗材料领域中应用的诱人候选物。
更新日期：2020-07-20
中文翻译：
具有高强度，形状记忆和吸附抗炎分子的多重氢键增强水凝胶。
对多种氢键（H键）水凝胶的研究逐渐引起了广泛的兴趣。在本文中，多氢键增强的聚（丙烯酰胺-共-2-乙烯基-4,6-二氨基-2-乙烯基-1,3,5-三嗪）/单宁酸（P（AM- CO -VDT制备）/ TA）水凝胶。结果表明，制备的水凝胶具有两种类型的H键交联区域：聚合物链上的二氨基三嗪（DAT）部分和TA邻苯三酚/邻苯二酚基团之间的H键“软”区域，以及“硬”区域DAT部分与其自身形成的H键区域。硬交联区显示出比软区高得多的活化能。这样的软，硬双物理交联的网络极大地提高P的机械特性（AM- CO-VDT）/ TA水凝胶的协同作用（抗张强度为2.34 MPa，断裂伸长率为410％）。由于存在多个氢键，因此水凝胶在几分钟内具有良好的pH敏感性和对形状记忆的快速响应。此外，水凝胶还具有物理吸附抗炎药双氯芬酸钠和其他具有特定空间排列化学成分的分子的能力。这些具有高机械强度，出色的形状记忆行为和抗炎药吸附能力的水凝胶可能是在生物医学，组织工程和医疗材料领域中应用的诱人候选物。
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