Bioactive Polylactide Fibrous Materials Prepared by Crazing Mechanism,Macromolecular Materials and Engineering

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Bioactive Polylactide Fibrous Materials Prepared by Crazing Mechanism
Macromolecular Materials and Engineering ( IF 4.2 ) Pub Date : 2020-06-21 , DOI: 10.1002/mame.202000163
Mukhamed A. Khavpachev _{1,

2} , Elena S. Trofimchuk ₁ , Nina I. Nikonorova ₁ , Elisaveta S. Garina ₁ , Marina A. Moskvina ₁ , Alexander V. Efimov ₁ , Varvara A. Demina _{2,

3} , Artem V. Bakirov _{2,

3} , Nikita G. Sedush _{2,

3} , Vladislav V. Potseleev ₁ , Tatiana A. Cherdyntseva ₁ , Sergei N. Chvalun _{2,

3}

Affiliation

Bioactive suture materials made of biodegradable polymers containing biologically active substances are increasingly demanded in contemporary surgical practice. Herein, the functional fibrous materials are produced by structural modification of polylactide (PLA) fibers according to the crazing mechanism in water–ethanol solutions. The threshold of ethanol concentration, at which the breaking elongation of the polymer substantially increases (up to 600–700%), is found to be 30 wt%. The crazing mechanism is employed to fill the porous structure of PLA fibers by different antiseptic substances (brilliant green, iodine, and fuchsin). PLA loaded by 0.8 wt% of brilliant green exhibits antimicrobial activity on Escherichia coli and Candida guilliermondii . The additive is released stepwise for a prolongated time period (2.5 months). The addition of 1–6 wt% iodine dramatically accelerates the polymer degradation in sodium‐phosphate buffer solution at 37 °C. The obtained filled fibers may possess great interest for producing suture materials with prolonged action of functional components and variable degradation times.

中文翻译：

裂纹机理制备的生物活性聚乳酸纤维材料

在当代外科实践中，越来越需要由含有生物活性物质的可生物降解的聚合物制成的生物活性缝合材料。在此，功能性纤维材料是根据水-乙醇溶液中的龟裂机理，通过对聚丙交酯（PLA）纤维进行结构改性而制成的。发现乙醇浓度的阈值为30 wt％，该阈值可使聚合物的断裂伸长率大幅增加（最高600-700％）。开裂机理用于通过不同的防腐剂（亮绿色，碘和品红）填充PLA纤维的多孔结构。载有0.8 wt％的亮绿色的PLA表现出对大肠杆菌和念珠菌的抗菌活性。添加剂会逐步释放，时间较长（2.5个月）。在37°C时，添加1-6 wt％的碘会显着加速聚合物在磷酸钠缓冲溶液中的降解。所获得的填充纤维对于具有功能部件的作用延长且降解时间可变的缝合线材料可能具有极大的兴趣。

更新日期：2020-07-16

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