BACKGROUND Yacón (Smallanthus sonchifolius) roots store carbohydrate in the form of prebiotic fructooligosaccharides (FOS), which improve intestinal health. Yacon has a potential to prevent the intestinal barrier alterations associated with colorectal cancer (CRC). This study aimed to investigate the preventive effects of yacón flour on alterations promoted by CRC induced by 1,2-dimethylhydrazine in rats. RESULTS CRC increased tumor necrosis factor alpha levels (CY = 10.2 ± 0.72; C = 9.6 ± 1.0; Y = 5.8 ± 0.54; S = 5.95 ± 0.6 pg/mL) and short chain fatty acid production, and decreased total antioxidant capacity (CY = 4.7 ± 0.72; C = 3.3 ± 0.3; Y = 4.1 ± 0.47; S = 6.7 ± 0.78 U/mL). Furthermore, YF treatment reduced intraluminal pH (CY = 6.45 ± 0.47; C = 7.65 ± 0.44; Y = 6.75 ± 0.46; S = 8.13 ± 0,2), lactulose/mannitol ratio, TNF-α/Interleukin (IL)-10 ratio, and increased secretory immunoglobulin A (CY = 9.48 ± 1.46; C = 10.95 ± 3.87; Y = 15.95 ± 7.36; S = 9.19 ± 1.52), but did not affect IL-10, IL-12, and TNF-α levels nor the IL-12/IL-10 ratio. CONCLUSION Yacón flour as a source of fructooligosaccharides may help to maintain the integrity of intestinal health, which is altered in induced CRC in rats. This article is protected by copyright. All rights reserved.

中文翻译：

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Yacón ( Smallanthus sonchifolius ) 在结直肠癌发生的动物模型中预防炎症、氧化应激和肠道改变

背景 Yacón (Smallanthus sonchifolius) 的根以益生元低聚果糖 (FOS) 的形式储存碳水化合物，从而改善肠道健康。Yacon 具有预防与结直肠癌 (CRC) 相关的肠道屏障改变的潜力。本研究旨在研究雪莲果粉对 1,2-二甲基肼诱导的大鼠结直肠癌改变的预防作用。结果 CRC 增加了肿瘤坏死因子 α 水平（CY = 10.2 ± 0.72；C = 9.6 ± 1.0；Y = 5.8 ± 0.54；S = 5.95 ± 0.6 pg/mL）和短链脂肪酸的产生，并降低了总抗氧化能力（CY = 4.7 ± 0.72；C = 3.3 ± 0.3；Y = 4.1 ± 0.47；S = 6.7 ± 0.78 U/mL）。此外，YF 治疗降低了管腔内 pH（CY = 6.45 ± 0.47；C = 7.65 ± 0.44；Y = 6.75 ± 0.46；S = 8.13 ± 0,2）、乳果糖/甘露醇比率，TNF-α/白细胞介素 (IL)-10 比率，以及分泌性免疫球蛋白 A 增加（CY = 9.48 ± 1.46；C = 10.95 ± 3.87；Y = 15.95 ± 7.36；S = 9.19 ± 1.52），但不影响 IL-10 、IL-12 和 TNF-α 水平也不是 IL-12/IL-10 比率。结论 Yacón 面粉作为低聚果糖的来源可能有助于维持肠道健康的完整性，这在大鼠诱导的 CRC 中发生了改变。本文受版权保护。版权所有。