Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China.,Journal of Medical Virology

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Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China.
Journal of Medical Virology ( IF 6.8 ) Pub Date : 2020-06-22 , DOI: 10.1002/jmv.26203
Tianxing Ji _{1,

2} , Ying Liu ₃ , Yaqing Li ₃ , Shahzad Akbar Khan ₄ , Qiang Zhou ₁ , Bo Chen ₁ , Zhen Lin ₁ , Xingchen Wang ₃ , Xianmiao Ye ₅ , Xuehua Zheng ₅ , Ling Chen _{2,

5} , Liqiang Feng ₅

Affiliation

The molecular prevalence of human adenoviruses (HAdVs) in Datong city and molecular evolution of HAdV‐C species is still obscure. Here, we explored the molecular prevalence of HAdVs by simultaneous sequencing of hexon and fiber. Then, the penton gene fragments of HAdV‐C species were determined by sequencing. Finally, genomic and proteotyping analysis were performed for exploration of molecular evolution of unique HAdV‐6. Our results showed that dominant molecular types of HAdVs were HAdV‐3, HAdV‐2, and HAdV‐1 based on the hexon and fiber genotype. Among H2F2 isolates, P1H2F2 was most common, followed by P2H2F2 and HAdV‐89. The clinical symptoms of HAdV‐1 or HAdV‐2 infected patients were more severe than HAdV‐3 infected patients, the prognosis of HAdV‐1, HAdV‐2, and HAdV‐3 infected patients was indifference. Genomic and proteotyping analysis demonstrated that DT15 was different from HAdV‐6 prototype, with high‐discrepant sequences localized in the E3 region. In conclusion, HAdV‐1 and HAdV‐2 have a high affinity to infect younger children and cause more severe symptoms than HAdV‐3. The E3 gene of HAdV‐C species was considered as highly recombination and mutation region.

更新日期：2020-06-22

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