Infections with bacterial pathogens often results in the initiation of programmed cell death as part of the host innate immune defense, or as a bacterial virulence strategy. Induction of host cell death is controlled by an elaborate network of innate immune and cell death signaling pathways and manifests in different morphologically and functionally distinct forms of death, such as apoptosis, necroptosis, NETosis and pyroptosis. The mechanism by which host cell death restricts bacterial replication is highly cell‐type and context depended, but its physiological importance is highlighted the diversity of strategies bacterial pathogens use to avoid induction of cell death or to block cell death signaling pathways. In this review, we discuss the latest insights into how bacterial pathogens elicit and manipulate cell death signaling, how different forms of cell death kill or restrict bacteria and how cell death and innate immune pathway cross talk to guard against pathogen‐induced inhibition of host cell death.

中文翻译：

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细胞内病原体与细胞死亡之间的串扰。

作为宿主先天免疫防御的一部分，或作为细菌毒力策略，细菌病原体感染通常会导致程序性细胞死亡的启动。宿主细胞死亡的诱导受先天免疫和细胞死亡信号通路的复杂网络控制，并表现为不同的形态和功能不同的死亡形式，例如细胞凋亡、坏死性凋亡、NETosis 和细胞焦亡。宿主细胞死亡限制细菌复制的机制高度依赖于细胞类型和环境，但其生理重要性突出了细菌病原体用来避免诱导细胞死亡或阻断细胞死亡信号通路的策略的多样性。在这篇综述中，我们讨论了关于细菌病原体如何引发和操纵细胞死亡信号的最新见解，