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Oxidative stress mediates rapid compensatory growth and its costs
Functional Ecology ( IF 4.6 ) Pub Date : 2020-06-19 , DOI: 10.1111/1365-2435.13616 Lizanne Janssens 1 , Robby Stoks 1
中文翻译：
氧化应激介导快速的代偿性增长及其成本
更新日期：2020-06-19
Functional Ecology ( IF 4.6 ) Pub Date : 2020-06-19 , DOI: 10.1111/1365-2435.13616 Lizanne Janssens 1 , Robby Stoks 1
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- While oxidative stress has been hypothesized to function both as a constraint on and a cost of growth, its mediatory role in shaping life history is still highly debated. Empirical studies about the role of oxidative stress in shaping growth responses and the associated costs are scarce and the two hypotheses have never been combined in one study.
- By directly manipulating oxidative stress, we tested its role in determining compensatory growth responses and the associated costs in the damselfly Lestes viridis. We reduced oxidative stress levels using the mitochondrial uncoupler 2,4‐dinitrophenol (DNP). To induce a compensatory growth response, half of the larvae in each oxidant treatment was exposed to a transient starvation period, after which food was present ad libitum.
- As expected, the transient starvation period induced a compensatory growth response, which was associated with increased oxidative damage and costs in terms of performance (reduced escape swimming speed) and physiology (reduced fat content). As expected, DNP exposure reduced oxidative stress and this resulted in the strongest compensatory growth response without any apparent costs and no increase in oxidative damage.
- By directly downregulating oxidative stress, our results are consistent with the hypothesis that the level of oxidative stress predictably determines the degree of the compensatory growth response and its associated costs. Our data therefore suggest a mediatory role of oxidative stress in shaping life history.
中文翻译：
氧化应激介导快速的代偿性增长及其成本
- 尽管氧化应激被认为既可作为生长的约束，又可作为生长的代价，但其在塑造生活史中的中介作用仍受到高度争议。关于氧化应激在影响生长反应和相关成本中的作用的实证研究很少，这两个假设从未在一项研究中结合在一起。
- 通过直接控制氧化应激，我们测试了其在决定豆娘Lestes viridis的代偿性生长反应及相关成本中的作用。我们使用线粒体解偶联剂2,4-二硝基苯酚（DNP）降低了氧化应激水平。为了诱导代偿性生长反应，每种氧化剂处理中的幼虫有一半暴露于短暂的饥饿时期，此后随意提供食物。
- 如预期的那样，短暂的饥饿期会引起代偿性生长反应，这与氧化损伤的增加和性能（降低的逃逸游泳速度）和生理（降低的脂肪含量）相关。不出所料，DNP暴露减少了氧化应激，这导致了最强的代偿性生长反应，而没有任何明显的成本，也没有增加氧化损伤。
- 通过直接下调氧化应激，我们的结果与以下假设一致：氧化应激的水平可预测地决定补偿性生长反应的程度及其相关成本。因此，我们的数据表明氧化应激在塑造生活史中起中介作用。
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