Striatal cholinergic interneurons exert inhibition on competing default behaviours controlled by the nucleus accumbens and dorsolateral striatum,European Journal of Neuroscience

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Striatal cholinergic interneurons exert inhibition on competing default behaviours controlled by the nucleus accumbens and dorsolateral striatum
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2020-06-22 , DOI: 10.1111/ejn.14873
Sivan Lian Ashkenazi _{1,

2} , Baruh Polis _{1,

3} , Orit David ₁ , Genela Morris _{1,

2}

Affiliation

With repeated practice, learned actions become more skilled, and eventually highly stereotypical. This transition is accompanied by a shift in striatal control over behaviour from ventral and dorsomedial striatum to dorsolateral striatum. The cholinergic interneurons (CINs) in the striatum are central to striatal computation. Yet, their role in the transition from motivated to stereotypic behaviour is still unclear. In this study, we examined whether CINs contribute to the competition between both control systems. We selectively lesioned CINs in the nucleus accumbens (NAc) or in the dorsolateral striatum (DLS) of rats trained in a cued maze task. After obtaining skilled performance, we manipulated the motivation for reward. While sparing task acquisition, selective lesions of the CINs had a marked dissociable impact on the sensitivity to motivation in the highly skilled state. Selective lesions of CINs increased automaticity of behaviour when performed in the DLS, but increased sensitivity to motivation in the NAc. These findings indicate a central role of CINs in regulating motivational impact on striatally controlled behaviours.

中文翻译：

纹状体胆碱能中间神经元对伏伏核和背外侧纹状体控制的竞争性默认行为产生抑制作用

通过反复练习，学到的动作将变得更加熟练，并最终成为刻板印象。这种转变伴随着对行为的纹状控制从腹侧和背侧纹状体向背外侧纹状体的转变。纹状体中的胆碱能中间神经元（CIN）是纹状体计算的中心。然而，它们在从动机行为向刻板印象的转变中所扮演的角色仍不清楚。在这项研究中，我们检查了CIN是否有助于两个控制系统之间的竞争。我们选择性地损害了在暗示的迷宫任务中训练的大鼠伏隔核（NAc）或背外侧纹状体（DLS）中的CIN。获得熟练的表演后，我们操纵了奖励的动机。在保留任务的同时，在高技能状态下，CIN的选择性病变对动机敏感性具有明显的可分解影响。在DLS中进行时，CIN的选择性病变增加了行为的自动性，但在NAc中对动机的敏感性增加了。这些发现表明，CIN在调节对纹状体行为的动机影响方面起着核心作用。

更新日期：2020-06-22

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