BODIPY on Board of Sugars: A Short Enlightened Journey up to the Cells,ChemPhotoChem

当前位置： X-MOL 学术 › ChemPhotoChem › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

BODIPY on Board of Sugars: A Short Enlightened Journey up to the Cells
ChemPhotoChem ( IF 3.0 ) Pub Date : 2020-06-22 , DOI: 10.1002/cptc.202000073
Anna Barattucci ₁ , Sebastiano Campagna ₁ , Teresa Papalia ₁ , Maurilio Galletta ₁ , Antonio Santoro ₁ , Fausto Puntoriero ₁ , Paola Bonaccorsi ₁

Affiliation

BODIPY dyes have unique properties including: good stability in many solvents, high extinction coefficients, stability to light, sharp fluorescence emissions in the visible region with high fluorescence quantum yields. Moreover, through small chemical modifications of the skeleton, their luminescence properties can be finely tuned. As a consequence, during the last decades, this family of chromophores found extensive application in a wide range of fields. Carbohydrates play a relevant role in living organisms: their tasks range from energy storage to structural constituents of cells and tissues, they are involved in a variety of molecular recognition phenomena of physiological and biological relevance. The cyclic structure of natural D‐monosaccharides, also offers the conditions to use carbohydrates as building‐blocks in the construction of more complex, supramolecular structures. With these assumptions, in the last years our research in this field has focused on the study of synthesis, the photophysical features, and the application in the biomedical field of molecules that bear the synergic presence of these two tools. Pointing on the rationalization of this research, this article will provide a synthetic review of our last‐year's results in the field of BODIPY/glycosyl species, that can be classified in two principal sections: a) the rational synthesis and the photophysical studies of BODIPY dyads and antennas containing different kind of sugar units as scaffolds, ranging from mono‐ to disaccharide patterns, and b) the synthetic functionalization and modification of suitable BODIPY structures, for their punctual application in the field of bio‐imaging.

中文翻译：

糖上的BODIPY：通往细胞的短暂启蒙之旅

BODIPY染料具有独特的特性，包括：在许多溶剂中均具有良好的稳定性，高消光系数，对光具有稳定性，在可见光区域具有清晰的荧光发射以及较高的荧光量子产率。此外，通过对骨架进行小的化学修饰，可以对它们的发光特性进行微调。结果，在过去的几十年中，该发色团家族在广泛的领域中得到了广泛的应用。碳水化合物在生物体中起着重要的作用：它们的任务范围从能量存储到细胞和组织的结构成分，它们涉及各种生理和生物学相关的分子识别现象。天然D-单糖的循环结构还提供了使用碳水化合物作为构建更复杂的超分子结构的基础的条件。基于这些假设，在过去的几年中，我们在这一领域的研究集中在具有这两种工具协同作用的分子的合成，光物理特征以及在生物医学领域的应用方面。指出这项研究的合理性，本文将对我们在BODIPY /糖基物质领域的去年研究成果进行综述，可分为以下两个主要部分：a）BODIPY的合理合成和光物理研究含有不同种类糖单元作为支架的二分体和触角，范围从单糖到双糖，

更新日期：2020-06-22

点击分享查看原文

点击收藏

阅读更多本刊最新论文