Front Cover: Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T1 MRI Contrast Agents (ChemMedChem 12/2020),ChemMedChem

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Front Cover: Binding and Release of FeIII Complexes from Glucan Particles for the Delivery of T1 MRI Contrast Agents (ChemMedChem 12/2020)
ChemMedChem ( IF 3.6 ) Pub Date : 2020-06-22 , DOI: 10.1002/cmdc.202000366
Akanksha Patel ₁ , Didar Asik ₁ , Eric M. Snyder ₁ , Alexandra E. Dilillo ₁ , Paul J. Cullen ₂ , Janet R. Morrow ₁

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The Front Cover shows yeast‐derived β‐glucan particles (GPs) loaded with a paramagnetic, high spin iron(III) coordination complex. The iron(III) complex is under development as a magnetic resonance imaging (MRI) contrast agent. The complex remains encapsulated in GPs under physiological conditions, and its water proton relaxivity is masked. Addition of the maltol chelator or mild acid releases the iron(III) complex from the GPs to restore the proton relaxivity of the complex as an MRI contrast agent. The cover art was inspired by Vincent van Gogh′s Starry Night. More information can be found in the Full Paper by Janet R. Morrow et al.

中文翻译：

封面：葡聚糖颗粒中FeIII复合物的结合和释放，用于递送T1 MRI造影剂（ChemMedChem 12/2020）

封面显示了酵母来源的β-葡聚糖颗粒（GPs），其中载有顺磁性，高自旋铁（III）配位化合物。铁（III）配合物正在开发为磁共振成像（MRI）造影剂。该复合物在生理条件下仍被封装在GP中，其水质子弛豫性被掩盖。麦芽酚螯合剂或弱酸的加入会从GP释放铁（III）络合物，以恢复该络合物作为MRI造影剂的质子弛豫性。封面艺术的灵感来自Vincent van Gogh的《星夜》。可以在Janet R. Morrow等人的论文全文中找到更多信息。

更新日期：2020-06-23

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