Emerging High-Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X).,BioEssays

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Emerging High-Level Tigecycline Resistance: Novel Tetracycline Destructases Spread via the Mobile Tet(X).
BioEssays ( IF 3.2 ) Pub Date : 2020-06-22 , DOI: 10.1002/bies.202000014
Liang-Xing Fang _{1,

2,

3} , Chong Chen ₁ , Chao-Yue Cui ₁ , Xing-Ping Li ₁ , Yan Zhang ₁ , Xiao-Ping Liao _{1,

2,

3} , Jian Sun _{1,

2,

3} , Ya-Hong Liu _{1,

2,

3}

Affiliation

Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine.

中文翻译：

新出现的高水平替加环素耐药性：通过 Mobile Tet(X) 传播的新型四环素破坏酶。

细菌的抗生素耐药性已成为对全球公共卫生的巨大威胁。替加环素是下一代四环素，是对抗泛耐药细菌病原体严重感染的最后一道防线。不幸的是，这种最后的抗生素受到了最近出现的可赋予高水平替加环素抗性的移动 Tet(X) 直向同源物的挑战。正如本文所述，这些新型四环素破坏酶对下一代四环素构成越来越大的威胁，并提供了了解它们的分子流行病学和耐药机制的基本框架。然而，

更新日期：2020-07-29

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