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Nephrotic syndrome and pulmonary hypertension as complications of intravenous drug abuse.
APMIS ( IF 2.2 ) Pub Date : 2020-06-21 , DOI: 10.1111/apm.13065
Janany Mohan 1 , Camilla J Nybø 2 , Johnny Vegsundvåg 1 , Borghild Roald 2, 3, 4 , Ylian S Liem 1, 5
Affiliation  

This case report discusses a patient with nephrotic syndrome, pulmonary hypertension, and repeated episodes of infections. He had a history of intravenous drug abuse. Kidney biopsy revealed the rare finding of numerous foam cells, mainly in glomeruli. The solvent used for the drugs is thought to be responsible for the foam cells. In line with previous reports, we suspect that the pulmonary hypertension is consistent with foam cells in pulmonary capillaries or fat embolism syndrome due to the intravenous administered drugs. Our case demonstrates that the use of intravenous drugs can lead to widely varying symptoms. Globally, the prevalence of substance abuse is increasing. Knowledge about their damaging effects is crucial in both clinical practice and anatomic pathology.

中文翻译:

肾病综合征和肺动脉高压为静脉吸毒的并发症。

该病例报告讨论了患有肾病综合征,肺动脉高压和反复感染的患者。他有静脉吸毒史。肾脏活检发现罕见的大量泡沫细胞发现,主要是肾小球。据认为,用于药物的溶剂是造成泡沫孔的原因。与先前的报道一致,我们怀疑由于静脉内给药,肺动脉高压与肺毛细血管或脂肪栓塞综合征中的泡沫细胞一致。我们的案例表明,静脉注射药物的使用会导致广泛不同的症状。在全球范围内,滥用药物的流行率正在上升。有关其破坏作用的知识在临床实践和解剖病理学中都至关重要。
更新日期:2020-07-28
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