Polyoxometalate-based drugs have been selected by some researchers as alternative antitumor substances with promising results in suppression of tumor growth because of low toxicity towards the human body and high activity. In this research, for the first time, nanolipid-loaded Preyssler polyoxometalate with diameters of 230–250 nm was synthesized and characterized by the Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Energy Dispersive X-Ray Analysis (EDAX), Atomic Force Microscopy (AFM), and Infrared (IR) spectroscopy. The nanoliposomes were found to be nearly spherical, without any agglomeration with the Entrapment Efficiency of 53.8%. In -vitro antitumor activity of the synthesized nanoliposomes was investigated using the MTT method on HepG2 tumor cells. Our findings showed enhanced anticancer activity for the nanolipid-loaded Preyssler (NLP) compared to the Sorafenib as a commercially drug at 72 h. Selectivity of the synthesized NLP and Sorafenib for cancer cells versus primary HFF cells was obtained as 4.2 and 2.2, respectively. The IC50 value of the loaded nanoliposomes for cancer cells and normal cells was equal to 470 and 2000 μg/mL, respectively at 72 h, which was much better compared to that of the Sorafenib (7 and 16 μg/mL, respectively).

由于对人体的低毒性和高活性，一些研究人员选择了基于多金属氧酸盐的药物作为替代的抗肿瘤药物，在抑制肿瘤生长方面有希望的结果。在这项研究中，首次合成了直径230-250 nm的纳米脂质负载的Preyssler多金属氧酸盐，并通过透射电子显微镜（TEM），扫描电子显微镜（SEM），能量色散X射线分析（EDAX）进行了表征。 ，原子力显微镜（AFM）和红外（IR）光谱。发现纳米脂质体几乎为球形，没有任何团聚，包封率为53.8％。体外使用MTT方法研究了合成的纳米脂质体对HepG2肿瘤细胞的抗肿瘤活性。我们的研究结果显示，与索拉非尼在72小时时作为商业药物相比，纳米脂质载Preyssler（NLP）的抗癌活性增强。合成的NLP和索拉非尼对癌细胞与原代HFF细胞的选择性分别为4.2和2.2。负载的纳米脂质体对癌细胞和正常细胞在72小时的IC50值分别等于470和2000μg/ mL，这比索拉非尼（分别为7和16μg/ mL）好得多。