A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.

中文翻译：

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由三溴异氰尿酸促进的苯乙烯和硫脲的一锅合成4-芳基-2-氨基噻唑

已经开发出一种简单有效的一锅法，用于使用容易获得的起始原料将苯乙烯转化为4-芳基-2-氨基噻唑。三溴异氰尿酸已成功用于苯乙烯的共溴化和氧化，得到苯甲酰溴，在硫脲存在下，苯甲酰苯能以48-70％的产率产生相应的4-芳基-2-氨基噻唑。该方案在一个过程中涉及三个反应：串联（由苯乙烯形成苯甲酰溴），然后进行伸缩（转化为噻唑）反应。