The TBHP-promoted selective radical addition of tetrahydrofuran to imines resulting in β-amino ethers has been developed. The presented radical method of β-amino ether synthesis is based on initiation by available TBHP and does not require metal catalysis or light irradiation. Variety of β-amino ethers are formed in good to excellent yields, despite the possible side oxidation pathways: ether α-oxidation, the transformation of starting imines into amides, target β-amino ethers dehydrogenation.

中文翻译：

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叔丁基过氧化氢辅助将四氢呋喃自由基加成至亚胺

已经开发了TBHP促进的四氢呋喃向亚胺的选择性自由基加成反应，生成β-氨基醚。提出的β-氨基醚合成的自由基方法是基于可用的TBHP引发的，不需要金属催化或光照射。尽管可能存在侧向氧化途径，但仍能以良好至极好的产率形成各种β-氨基醚：醚α-氧化，起始亚胺转化为酰胺，目标β-氨基醚脱氢。