Acetone detection in exhaled breath as a biomarker has been a new method for non-invasive diagnosis of diabetes in medical diagnosis. Here, we fabricated a stabilized zirconia (YSZ) solid electrolyte type acetone sensor based on mixed potential sensing mechanism using Fe₂TiO₅-TiO₂ oxide sensing electrode (SE) prepared by a simple sol-gel method. The acetone sensing performance of the fabricated sensor attached with Fe₂TiO₅-TiO₂-SE calcined at 1200℃ was evaluated at different working temperatures from 490℃ to 640℃. The sensor exhibits the highest response values at all the evaluated concentrations of acetone at 590℃, which even detects as low as 100 ppb acetone with the response value of -2.9 mV. The sensor displays high sensitivities of −13 mV/decade and −46 mV/decade in the acetone concentration ranges of 0.1 ppm – 1 ppm and 1 ppm – 20 ppm, respectively. Meanwhile, the selectivity, reproducibility, humidity/time stability of the developed sensing device are still impressive. Moreover, the breath analysis of healthy volunteers and diabetic volunteers was discussed to verify the application value of the sensor. The good acetone detectability of the developed sensor provides a potential for routine monitoring and early screening of diabetics.

呼气中的丙酮检测作为生物标志物已成为医学诊断中非侵入性诊断糖尿病的一种新方法。在这里，我们使用通过简单的溶胶-凝胶法制备的Fe ₂ TiO ₅ -TiO ₂氧化物感测电极（SE），基于混合电位感测机制制造了稳定的氧化锆（YSZ）固体电解质型丙酮传感器。Fe ₂ TiO ₅ -TiO ₂附着传感器的丙酮感测性能在490℃至640℃的不同工作温度下评估了1200℃煅烧的-SE。在所有评估的丙酮浓度下，传感器在590℃时都显示出最高的响应值，甚至可以检测到低至100 ppb的丙酮，响应值为-2.9 mV。传感器在0.1 ppm – 1 ppm和1 ppm – 20 ppm的丙酮浓度范围内分别显示出-13 mV /十倍和-46 mV /十倍的高灵敏度。同时，开发的传感装置的选择性，可再现性，湿度/时间稳定性仍然令人印象深刻。此外，讨论了健康志愿者和糖尿病志愿者的呼吸分析，以验证传感器的应用价值。发达的传感器对丙酮的良好检测能力为糖尿病的常规监测和早期筛查提供了可能。