Research question

Is there a difference in ovarian reserve biomarkers and ovarian response between the right and left ovaries of infertile women undergoing IVF treatments?

Design

A total of 100 infertile women aged 27 to 37 years, diagnosed with either unexplained male factor or mechanical factor infertility, participated in the study. All women had both ovaries intact, and regular menstrual cycles with no previous diagnosis of polycystic ovaries or endometriosis. The data were collected separately for each ovary, and included parameters of basal sonographic ovarian reserve, as well as ovarian response to ovarian stimulation.

Results

Basal sonographic ovarian reserve markers were similar between the two ovaries. The right and left ovaries did not differ in their basal antral follicle count (AFC) (6.9 ± 3.9 versus 6.8 ± 3.8, respectively, P = 0.672), nor did they differ in their ovarian volume (10.3 ± 6.7 versus 9.8 ± 8.0 cm³, respectively, P = 0.636). Nevertheless, a superior right-sided ovarian response to ovarian stimulation was observed, with a significantly higher total number of follicles in the right compared with the left ovary (7.8 ± 4.3 versus 6.8 ± 4.2 follicles, respectively, P = 0.006), and a higher number of follicles ≥14 mm on the day of human chorionic gonadotrophin administration (4.9 ± 3.2 versus 3.8 ± 2.4 follicles, respectively, P = 0.002).

Conclusions

Despite comparable basal AFC and ovarian volume, the two ovaries are distinguishable in their response to ovarian stimulation with a clear right-side preference. These findings imply that the superiority of right ovarian response may be derived from local pelvic factors, presumably a more efficient vascularization.

中文翻译：

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左右卵巢之间的卵巢储备生物标志物和卵巢反应是否存在差异？

研究问题

接受试管婴儿治疗的不孕女性的左右卵巢在卵巢储备生物标志物和卵巢反应方面是否存在差异？

设计

共有 100 名年龄在 27 至 37 岁之间的不孕女性，被诊断为不明原因的男性因素或机械因素不孕，参与了这项研究。所有女性的卵巢都完好无损，月经周期规律，之前没有诊断出多囊卵巢或子宫内膜异位症。每个卵巢的数据分别收集，包括基础超声卵巢储备的参数，以及卵巢对卵巢刺激的反应。

结果

两个卵巢的基础超声卵巢储备标志物相似。左右卵巢的基底窦卵泡计数 (AFC) 没有差异（分别为 6.9 ± 3.9 和 6.8 ± 3.8，P  = 0.672），它们的卵巢体积也没有差异（10.3 ± 6.7 和 9.8 ± 8.0 cm ³，分别为P  = 0.636）。尽管如此，观察到右侧卵巢对卵巢刺激的反应更好，与左侧卵巢相比，右侧的卵泡总数显着更高（分别为 7.8 ± 4.3 和 6.8 ± 4.2 个卵泡，P  = 0.006），并且在人绒毛膜促性腺激素给药当天，≥14 mm 的卵泡数量更多（分别为 4.9 ± 3.2 和 3.8 ± 2.4 个卵泡，P = 0.002）。

结论

尽管基础 AFC 和卵巢体积相当，但两个卵巢在对卵巢刺激的反应方面是可区分的，并且具有明显的右侧偏好。这些发现意味着右侧卵巢反应的优越性可能来自局部盆腔因素，可能是更有效的血管化。