Abstract Blend uniformity is a critical quality attribute in continuous pharmaceutical manufacturing. However, its measurement is challenging due to the difficulty and inaccessibility of sampling locations in a continuous blender. Though computational approaches like Discrete Element Method (DEM) can address this, one of the underlying challenges is the appropriate selection of mixing index for measurement of blend uniformity. Given the wide plethora of literature implementing different indices, it becomes cumbersome to identify suitable index for specific blending application. The proposed article aims to address this concern using a detailed review, classification and comparison of existing mixing indices. These indices are used to evaluate mixing in a periodic section of blender using DEM. The effects of process parameters, like blade speed, on mixing are further investigated. This review article, thus, contributes towards devising a systematic strategy for selection of appropriate mixing index based on the powder system and its application.

中文翻译：

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对基于固体的连续混合操作中现有混合指标的审查

摘要 混合均匀度是连续制药生产中的一个关键质量属性。然而，由于连续搅拌机中采样位置的困难和不可接近性，其测量具有挑战性。Though computational approaches like Discrete Element Method (DEM) can address this, one of the underlying challenges is the appropriate selection of mixing index for measurement of blend uniformity. 鉴于实施不同指数的文献过多，为特定混合应用确定合适的指数变得很麻烦。拟议的文章旨在通过对现有混合指数的详细审查、分类和比较来解决这一问题。这些指标用于使用 DEM 评估搅拌机周期部分中的混合。工艺参数的影响，如叶片速度，对混合进行进一步研究。因此，这篇评论文章有助于设计一种基于粉末系统及其应用选择合适混合指标的系统策略。