Triterpenoids from the stems and leaves of Schisandra incarnata,Phytochemistry

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Triterpenoids from the stems and leaves of Schisandra incarnata
Phytochemistry ( IF 3.2 ) Pub Date : 2020-09-01 , DOI: 10.1016/j.phytochem.2020.112448
Ming Zhou ₁ , Xiaogang Peng ₂ , Jia Zhou ₂ , Ye Liu ₁ , Xianggao Meng ₃ , Hanli Ruan ₂

Affiliation

Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra incarnata Stapf. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of schincarin A was corroborated by analysis of the experimental ECD spectrum, and single-crystal X-ray diffraction with Mo Kα irradiation. Schincarin A represented the first example of preschisanartane-type triterpenoid with two oxa-bridged hemiketals. Among the selected compounds which were evaluated for immunosuppressive activities, schincarin C and kadsudilactone A showed potential inhibition against ConA-induced T-cell proliferation with IC50 values of 5.83 and 6.32 μM, and LPS-induced B cell proliferation with IC50 values of 10.21 and 11.49 μM, respectively.

中文翻译：

五味子茎叶中的三萜类化合物

六种未描述的三萜类化合物，schincarins A-F，归类为 preschisanartane (schincarin A)，3,4-secocycloartane (schincarins B-D)，3,4；从五味子的茎和叶中获得了 9,10-二十二烷环戊烷 (schincarin E) 和 3,4-secolanostane (schincarin F) 类，以及十二种已知的类似物。在广泛的光谱分析的基础上阐明了它们的结构。schincarin A 的绝对构型通过实验 ECD 光谱的分析和 Mo Kα 辐照的单晶 X 射线衍射得到证实。Schincarin A 代表了具有两个氧杂桥联半缩酮的 preschisanartane 型三萜的第一个例子。在评估免疫抑制活性的选定化合物中，

更新日期：2020-09-01

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