Abstract The combination of methyldopa and hydrocholorothiazide are used to treat high blood pressure. The present research dealt with the synthesis and utilization of the hexagonal-shaped of ZnO nanoparticles (NPs) to develop a new, sensitive, and exclusive electrochemical sensor for detection of methyldopa. Thus, we did our examination on the methyldopa detection via cyclic voltammetry (CV) method, differential pulse voltammetry (DPV) technique, and chronoamperometry (CH) at molybdenum (VI) complex-ionic liquid–ZnO NP modified carbon paste electrode (MCILZNMCPE) in 0.1 M PBS (pH of 7.0) solution. The use of DPV showed linear dependence of methyldopa peak current at pH of 7.0 solution on their concentration ranging between 0.05 and 300.0 µM. Then, limit of detection (LOD) has been determined to be 20.0 nM for methyldopa. Ultimately, the modified electrode has been utilized for detecting methyldopa in the presence of hydrochlorothiazide by DPV.

中文翻译：

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实际样品中氢氯噻嗪存在下甲基多巴的电催化氧化和选择性伏安检测

摘要 甲基多巴联合氢氯噻嗪用于治疗高血压。目前的研究涉及六边形 ZnO 纳米粒子 (NPs) 的合成和利用，以开发一种新的、灵敏的、独特的用于检测甲基多巴的电化学传感器。因此，我们通过循环伏安法 (CV) 法、微分脉冲伏安法 (DPV) 技术和计时电流法 (CH) 在钼 (VI) 复合离子液体-ZnO NP 改性碳糊电极 (MCILZNMCPE) 上对甲基多巴检测进行了检查在 0.1 M PBS（pH 值为 7.0）溶液中。DPV 的使用表明，在 pH 值为 7.0 的溶液中，甲基多巴峰值电流与其浓度范围在 0.05 和 300.0 µM 之间呈线性关系。然后，已确定甲基多巴的检测限 (LOD) 为 20.0 nM。最终，