Biomaterials Advances ( IF 5.5 ) Pub Date : 2020-06-22 , DOI: 10.1016/j.msec.2020.111230 Christopher Narh 1 , William Badoe 2 , Ebenezer Kofi Howard 2 , Nie Xiao Lin 1 , Alfred Mensah 1 , Tingting Wang 1 , Qingqing Wang 1 , Fenglin Huang 1 , Qufu Wei 1
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Inulin as an external carbon source was used as the fructose substitute to Gluconacetobacter xylinus (ATCC 10245) bacterial strain in a successful synthesis of cellulosic pockets to be used in drug delivery and storage. It was observed that inulobiose trans conformation was in agreement with ϕ = Ψ = ω = 180° and angular rotation of ϴ (C1-C2-0-CI'′), ϴ (C2-0-C 1′-C2′) and ϴ (0-C1′-C2′-0′) respectively. A bacterial susceptibility test revealed a successful inactivation of Staphylococcus aureus and Escherichia coli in the presence of photons. Fourier Transform Infrared Spectroscopy analysis confirmed an OH absorption was verified at 3423 cm−1. Pocket drug uptake test revealed a highly absorbent structure with the thermal stability directly proportional to the increase in drug uptake, while the increase in the degree of polymerization resulted in the increase in antioxidant activity and rate of bacterial inactivation.
Hypothesis
Inulin as an inert polysaccharide is neutral to cellular activity, therefore, could not be an agent for bacteria inactivation.
中文翻译：
合成的富含OH自由基的细菌纤维素囊，具有针对金黄色葡萄球菌和大肠杆菌的光动力细菌灭活特性。
菊粉作为外部碳源被用作木糖葡糖杆菌（ATCC 10245）细菌菌株的果糖替代品，成功合成了可用于药物输送和存储的纤维素囊袋。观察到inulobiose反式构象与ϕ =Ψ=ω= 180°和ϴ（C1-C2-0-CI''），ϴ（C2-0-C 1'-C2'）和分别为（0-C1'-C2'-0'）。细菌敏感性测试表明，在光子存在下，金黄色葡萄球菌和大肠杆菌成功失活。傅立叶变换红外光谱分析证实在3423 cm -1处证实了OH的吸收。袋装药物吸收测试显示出高度吸收的结构，其热稳定性与药物吸收的增加成正比，而聚合度的增加导致抗氧化剂活性和细菌灭活率的增加。
假设
菊粉作为一种惰性多糖对细胞活性是中性的，因此不能作为细菌灭活剂。
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