In stomatology, the promotion of alveolar bone regeneration while preventing the reduction of ridge absorption remains a challenge. In this work, we designed and prepared bio-mimetic polysaccharide hydrogels that are multi-functional in terms of being injectable, promote self-healing, degradable, porous structure, et al. After introducing nano-hydroxyapatite particles, the composite scaffold of hydrogel/hydroxyapatite (GH) stent was obtained. When GH material was injected into the mandibular incisors of rats following tooth extraction, the new bone area was enhanced more than 50%, while the alveolar ridge was promoted in excess of 60% after 4 weeks. What's more, the wound soft tissue was healed within 1 week. Overall, our results indicate that this optimized GH stent has the potential to both maintain dimensional alveolar ridge, as well as to promote soft tissue healing. Moreover, using the hydroxyapatite-containing hydrogel platform has the potential to promote bone and soft tissue regeneration.

在口腔医学中，在防止牙槽absorption吸收减少的同时，促进牙槽骨再生仍然是一个挑战。在这项工作中，我们设计并制备了仿生多糖水凝胶，它们具有可注射性，促进自我修复，可降解，多孔结构等多种功能。引入纳米羟基磷灰石颗粒后，得到了水凝胶/羟基磷灰石（GH）支架的复合支架。在拔牙后将GH材料注射到大鼠的下颌切牙中后，新骨面积增加了50％以上，而牙槽则在4周后增加了60％以上。此外，伤口的软组织在1周内就愈合了。总体而言，我们的结果表明，这种优化的GH支架既可以维持尺寸的牙槽，以及促进软组织愈合。而且，使用含羟基磷灰石的水凝胶平台具有促进骨骼和软组织再生的潜力。