Synergistic antibacterial strategies have received growing attention due to their significantly enhanced antibacterial activity. Herein, we demonstrated a synergistic antibacterial strategy based on streptomycin sulfate (SS) loaded polyethylene glycol-MoS₂/reduced graphene oxide (PEG-MoS₂/rGO) nanoflakes assisted with near-infrared (NIR). The nanoflakes of PEG-MoS₂/rGO were ultrasonically exfoliated well from the nanoflowers of PEG-MoS₂/rGO fabricated by hydrothermal method, which was of antibacterial activity against Staphylococcus aureus and Escherichia coli after loading of SS. Under the irradiation of NIR, the antibacterial activity was significantly enhanced by the synergistic effects of physical damage, protein synthesis inhibition, thermal injury and oxidative stress. Moreover, the cytotoxicity of the nanoflakes was very low. The results suggest the great potential of PEG-MoS₂/rGO-SS as a photothermal antibacterial agent.

协同抗菌策略由于其显着增强的抗菌活性而受到越来越多的关注。在这里，我们展示了基于硫酸链霉素（SS）负载的聚乙二醇-MoS ₂ /氧化石墨烯（PEG-MoS ₂ / rGO）纳米片和近红外（NIR）辅助的协同抗菌策略。从水热法制备的PEG-MoS ₂ / rGO纳米花中，超声剥落PEG-MoS ₂ / rGO纳米片，对金黄色葡萄球菌和大肠杆菌具有抗菌活性。加载SS之后。在近红外照射下，物理损伤，蛋白质合成抑制，热损伤和氧化应激的协同作用显着增强了抗菌活性。此外，纳米薄片的细胞毒性非常低。结果表明PEG-MoS ₂ / rGO-SS作为光热抗菌剂的巨大潜力。