We report potentiation of healing efficacy of alginate by value addition at its structural level. Dual crosslinked (ionically and covalently) sodium alginate hydrogel coupled with honey (HSAG) brings about an intermediate stiffness in the fabric, confers consistent swelling property and limits erratic degradation of the polymer which ultimately provides conducive milieu to cellular growth and proliferation. In this work honey concentrations in HSAGs are varied from 2% to 10%. FTIR, XRD and nanoindentation studies on the HSAGs exhibited physicochemical integrity. In vitro degradation study provided the crucial finding on 4% HSAG having controlled degradation rate up to 12 days with a weight loss of 87.36 ± 1.14%. This particular substrate also has an ordered crystalline surface morphology with decent cellular viability (HaCaT and 3T3) and antimicrobial potential against Methicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli. The in vivo wound contraction kinetics on murine models (4% HSAG treated wound contraction: 94.56 ± 0.1%) has been monitored by both invasive (histopathology) and noninvasive (Swept Source Optical Coherence Tomography) imaging and upon corroborating them it evidenced that 4% HSAG treated wound closure achieved epithelial thickness resembling to that of unwounded skin. Thus, the work highlights structurally modified alginate hydrogel embedded with honey as a potential antimicrobial healing agent.

我们通过在结构水平上增加价值来报告藻酸盐的治愈功效增强。海藻酸钠水凝胶与蜂蜜（HSAG）的双重交联（离子和共价）使织物具有中等刚度，赋予织物一致的溶胀性，并限制了聚合物的不稳定降解，最终为细胞的生长和增殖提供了有利的环境。在这项工作中，HSAGs中的蜂蜜浓度从2％到10％不等。HSAGs的FTIR，XRD和纳米压痕研究显示出理化完整性。体外降解研究提供了关键的发现，即4％的HSAG具有可控制的降解速率（长达12天）和87.36±1.14％的失重。金黄色葡萄球菌（MRSA）和大肠杆菌。在体内对鼠科动物模型伤口收缩的动力学（4％HSAG治疗的伤口收缩：94.56±0.1％）已经由侵入性（病理组织学）和非侵入性（扫频光源光学相干断层扫描）成像监测并且在证实他们它证明该4％ HSAG处理的伤口闭合的上皮厚度类似于未受伤的皮肤。因此，这项工作着重强调了嵌入蜂蜜中作为潜在抗菌治疗剂的结构改性藻酸盐水凝胶。